70
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      scite_
      Version and Review History
       
      • Record: found
      • Abstract: found
      • Conference Proceedings: found
      Is Open Access

      Network-based therapeutic approach for brain ischemia: A broad therapy for a specific patient

      conference-abstract
      This is not the latest version for this article. If you want to read the latest version, click here.
      Bookmark

            Abstract

            Despite years of efforts, translational stroke research has yield to no neuroprotective therapy. Moreover, only single-drug targets remain hitherto being pursued whilst we know that complex diseases are defined by multitarget modules which should be tackled simultaneously. Therefore, we here propose a network-based approach for multi-target identification based on human disease genes linked to ischemic stroke, in combination with a network pharmacology, drug repurposing therapeutic approach. Indeed, network pharmacology exploits this concept by simultaneously targeting several components of an impaired signalling pathway, using mechanistically related and thus synergistic drugs with a maximal therapeutic effect. However, it remains evident that not all stroke patients suffer from the same dysregulated mechanisms upon stroke. Then, we propose to combine a network pharmacology therapeutic approach with diagnostic endothenotyping of patients who could maximally benefit from our proposed therapy; thus ensuring a personalised, mechanism-based, synergistic therapy with a quick access to the pharmaceutic market.

            Content

            Author and article information

            Conference
            RExPO24 Conference
            REPO4EU
            6 May 2024
            Affiliations
            [1 ] University Hospital Essen ( https://ror.org/02na8dn90)
            [2 ] Maastricht University ( https://ror.org/02jz4aj89)
            Author notes
            Author information
            https://orcid.org/0000-0002-0935-074X
            Article
            10.58647/REXPO.24000061.v1
            027fec9f-78c7-408c-8e6f-ea5394c6b3a6

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            RExPO24
            3
            Munich, Germany
            3-5 July 2024
            History
            : 3 May 2024
            Categories

            The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
            Pharmacology & Pharmaceutical medicine
            Brain ischemia,Network pharmacology,Drug repurposing,Disease module,Synergy

            Comments

            Comment on this article