The third century marked a profound change in the urban landscape of Ephesus and proved to exert a profound influence on the city's later development. There is conclusive evidence for catastrophic disasters when the city was afflicted by a series of earthquakes which led to a temporary downturn in its economic circumstances. These destructive earthquakes not only had long-term consequences for the city's appearance, but also affected the very foundations of urbanism. This chapter traces the history of Metropolis Asiae after the earthquakes of the third and fourth centuries. The archaeological evidence proves that rebuilding took place and within public areas, such as agorae or buildings along the roads and included fountains and baths. The work was not limited only to the reconstruction of buildings but efforts were made to restore the splendid appearance of the city, reflecting the restoration of its high urban status and commercial importance. This chapter also describes the city's numerous churches that graphically attest to the growing importance of Christianity as the state religion.