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Exclusive: NIH to terminate hundreds of active research grants

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Open Access

A radio transient with unusually slow periodic emission

The high-frequency radio sky is bursting with synchrotron transients from massive stellar explosions and accretion events, but the low-frequency radio sky has so far been quiet beyond the Galactic pulsar population and the long-term scintillation of AGN. The low-frequency band, however, is sensitive to exotic coherent and polarised radio emission processes such as electron cyclotron maser emission from flaring M-dwarfs [1], stellar magnetospheric plasma interactions with exoplanets [2], and a population of steep-spectrum pulsars [3], making Galactic plane searches a prospect for blind transient discovery. Here we report an analysis of archival low-frequency radio data that reveals a periodic, low-frequency radio transient. We find that the source pulses every 18.18 minutes, an unusual periodicity not previously observed. The emission is highly linearly polarised, bright, persists for 30--60 s on each occurrence, and is visible across a broad frequency range. At times the pulses comprise short (<0.5-s) duration bursts; at others, a smoother profile is observed. These profiles evolve on timescales of hours. By measuring the dispersion of the radio pulses with respect to frequency, we have localised the source to within our own Galaxy, and suggest that it could be an ultra-long period magnetar.

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Rapid butterfly declines across the United States during the 21st century

Numerous declines have been documented across insect groups, and the potential consequences of insect losses are dire. Butterflies are the most surveyed insect taxa, yet analyses have been limited in geographic scale or rely on data from a single monitoring program. Using records of 12.6 million individual butterflies from >76,000 surveys across 35 monitoring programs, we characterized overall and species-specific butterfly abundance trends across the contiguous United States. Between 2000 and 2020, total butterfly abundance fell by 22% across the 554 recorded species. Species-level declines were widespread, with 13 times as many species declining as increasing. The prevalence of declines throughout all regions in the United States highlights an urgent need to protect butterflies from further losses.

Reports of declining insect populations have received widespread media attention, but evidence for declines has been variable across regions and taxonomic groups. Edwards et al . examined trends in the most surveyed taxon: butterflies (see the Perspective by Inouye). Combining data from 35 citizen science programs across the continental US, the authors found declines in overall butterfly abundance over the past 20 years across almost all major regions. Two-thirds of studied species showed declines of more than 10%. Many insects have the potential for rapid population growth and recovery, but habitat restoration, species-specific interventions, and reducing pesticide use are all likely needed to curb population declines. —Bianca Lopez

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Butter and Plant-Based Oils Intake and Mortality

Importance

The relationship between butter and plant-based oil intakes and mortality remains unclear, with conflicting results from previous studies. Long-term dietary assessments are needed to clarify these associations.

Objective

To investigate associations of butter and plant-based oil intakes with risk of total and cause-specific mortality among US adults.

Design, Setting, and Participants

This prospective population-based cohort study used data from 3 large cohorts: the Nurses’ Health Study (1990-2023), the Nurses’ Health Study II (1991-2023), and the Health Professionals Follow-up Study (1990-2023). Women and men who were free of cancer, cardiovascular disease (CVD), diabetes, or neurodegenerative disease at baseline were included.

Exposures

Primary exposures included intakes of butter (butter added at the table and from cooking) and plant-based oil (safflower, soybean, corn, canola, and olive oil). Diet was assessed by validated semiquantitative food frequency questionnaires every 4 years.

Main Outcomes and Measures

Total mortality was the primary outcome, and mortality due to cancer and CVD were secondary outcomes. Deaths were identified through the National Death Index and other sources. A physician classified the cause of death based on death certificates and medical records.

Results

During up to 33 years of follow-up among 221 054 adults (mean [SD] age at baseline: 56.1 [7.1] years for Nurses’ Health Study, 36.1 [4.7] years for Nurses’ Health Study II, and 56.3 [9.3] years for Health Professionals Follow-up Study), 50 932 deaths were documented, with 12 241 due to cancer and 11 240 due to CVD. Participants were categorized into quartiles based on their butter or plant-based oil intake. After adjusting for potential confounders, the highest butter intake was associated with a 15% higher risk of total mortality compared to the lowest intake (hazard ratio [HR], 1.15; 95% CI, 1.08-1.22; P for trend &amp;lt; .001). In contrast, the highest intake of total plant-based oils compared to the lowest intake was associated with a 16% lower total mortality (HR, 0.84; 95% CI, 0.79-0.90; P for trend &amp;lt; .001). There was a statistically significant association between higher intakes of canola, soybean, and olive oils and lower total mortality, with HRs per 5-g/d increment of 0.85 (95% CI, 0.78-0.92), 0.94 (95% CI, 0.91-0.96), and 0.92 (95% CI, 0.91-0.94), respectively (all P for trend &amp;lt; .001). Every 10-g/d increment in plant-based oils intake was associated with an 11% lower risk of cancer mortality (HR, 0.89; 95% CI, 0.85-0.94; P for trend &amp;lt; .001) and a 6% lower risk of CVD mortality (HR, 0.94; 95% CI, 0.89-0.99; P for trend = .03), whereas a higher intake of butter was associated with higher cancer mortality (HR, 1.12; 95% CI, 1.04-1.20; P for trend &amp;lt; .001). Substituting 10-g/d intake of total butter with an equivalent amount of total plant-based oils was associated with an estimated 17% reduction in total mortality (HR, 0.83; 95% CI, 0.79-0.86; P &amp;lt; .001) and a 17% reduction in cancer mortality (HR, 0.83; 95% CI, 0.76-0.90; P &amp;lt; .001).

Conclusions and Relevance

In this cohort study, higher intake of butter was associated with increased mortality, while higher plant-based oils intake was associated with lower mortality. Substituting butter with plant-based oils may confer substantial benefits for preventing premature deaths.

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Open Access

Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

    (2025)
Background

Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic.

Methods

We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy.

Findings

All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy across all countries (overall mean –0·18 years [95% UI –0·22 to –0·13]), with all countries having an absolute fall in life expectancy except for Ireland, Iceland, Sweden, Norway, and Denmark, which showed marginal improvement in life expectancy, and Belgium, which showed no change in life expectancy. Across countries, the causes of death responsible for the largest improvements in life expectancy from 1990 to 2011 were cardiovascular diseases and neoplasms. Deaths from cardiovascular diseases were the primary driver of reductions in life expectancy improvements during 2011–19, and deaths from respiratory infections and other COVID-19 pandemic-related outcomes were responsible for the decreases in life expectancy during 2019–21. Deaths from cardiovascular diseases and neoplasms in 2019 were attributable to high systolic blood pressure, dietary risks, tobacco smoke, high LDL cholesterol, high BMI, occupational risks, high alcohol use, and other risks including low physical activity. Exposure to these major risk factors differed by country, with trends of increasing exposure to high BMI and decreasing exposure to tobacco smoke observed in all countries during 1990–2021.

Interpretation

The countries that best maintained improvements in life expectancy after 2011 (Norway, Iceland, Belgium, Denmark, and Sweden) did so through better maintenance of reductions in mortality from cardiovascular diseases and neoplasms, underpinned by decreased exposures to major risks, possibly mitigated by government policies. The continued improvements in life expectancy in five countries during 2019–21 indicate that these countries were better prepared to withstand the COVID-19 pandemic. By contrast, countries with the greatest slowdown in life expectancy improvements after 2011 went on to have some of the largest decreases in life expectancy in 2019–21. These findings suggest that government policies that improve population health also build resilience to future shocks. Such policies include reducing population exposure to major upstream risks for cardiovascular diseases and neoplasms, such as harmful diets and low physical activity, tackling the commercial determinants of poor health, and ensuring access to affordable health services.

Funding

Gates Foundation.

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Open Access

Ancient ocean coastal deposits imaged on Mars

Various observations suggest that large amounts of liquid water once existed on the Martian surface, however, the nature and fate of this water are uncertain. Through radar data gathered by the Zhurong Rover, we identify extensive dipping deposits in the subsurface of southern Utopia Planitia. These deposits have structures similar to those of Earth’s coastal sediments. This finding implies the past existence of a large water body, supporting the hypothesis of a past ocean in the northern plains of Mars.

The northern lowlands of early Mars could have contained a significant quantity of liquid water. However, the ocean hypothesis remains controversial due to the lack of conclusive evidence from the Martian subsurface. We use data from the Zhurong Rover Penetrating Radar on the southern Utopia Planitia to identify subsurface dipping reflectors indicative of an ancient prograding shoreline. The reflectors dip unidirectionally with inclinations in the range 6° to 20° and are imaged to a thickness of 10 to 35 m along an uninterrupted 1.3 km northward shoreline-perpendicular traverse. The consistent dip inclinations, absence of dissection by fluvial channels along the extended traverse, and low permittivity of the sediments are consistent with terrestrial coastal deposits—and discount fluvial, aeolian, or magmatic origins favored elsewhere on Mars. The structure, thickness, and length of the section support voluminous supply of onshore sediments into a large body of water, rather than a merely localized and short-lived melt event. Our findings not only provide support for the existence of an ancient Martian ocean in the northern plains but also offer crucial insights into the evolution of the ancient Martian environment.

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Open Access

A long-period radio transient active for three decades

Recently several long-period radio transients have been discovered, with strongly polarised coherent radio pulses appearing on timescales between tens to thousands of seconds [1,2]. In some cases the radio pulses have been interpreted as coming from rotating neutron stars with extremely strong magnetic fields, known as magnetars; the origin of other, occasionally periodic and less well-sampled radio transients, is still debated [3]. Coherent periodic radio emission is usually explained by rotating dipolar magnetic fields and pair production mechanisms, but such models do not easily predict radio emission from such slowly-rotating neutron stars and maintain it for extended times. On the other hand, highly magnetic isolated white dwarfs would be expected to have long spin periodicities, but periodic coherent radio emission has not yet been directly detected from these sources. Here we report observations of a long-period (21 minutes) radio transient, which we have labeled GPMJ1839-10. The pulses vary in brightness by two orders of magnitude, last between 30 and 300 seconds, and have quasi-periodic substructure. The observations prompted a search of radio archives, and we found that the source has been repeating since at least 1988. The archival data enabled constraint of the period derivative to <3.6×1013s s1, which is at the very limit of any classical theoretical model that predicts dipolar radio emission from an isolated neutron star.

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Open Access

Direct hydroxyproline radiocarbon dating of the Lapedo child (Abrigo do Lagar Velho, Leiria, Portugal)

The 1998 discovery of a nearly intact Gravettian human burial in the Lapedo Valley (Leiria, Portugal) propelled the Lagar Velho rockshelter to worldwide fame. The ochre-stained skeleton of the Lapedo child, a juvenile aged around four or five, exhibited a mosaic of Neanderthal and anatomically modern human features argued to reflect admixture between the two human populations. Here, we present direct compound-specific radiocarbon dates for the child’s skeleton [27,780 to 28,550 calibrated years before present (cal B.P.)] and five associated bones from the burial and underlying contexts. We reassess the chronology and archaeological interpretation of the burial in light of these new dates and demonstrate the suitability of hydroxyproline radiocarbon dating for poorly preserved Paleolithic samples that otherwise fail routine radiocarbon pretreatment methods.

The Lapedo child is now firmly dated to 27,780 to 28,550 cal B.P.

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Open Access

The first and most complete dinosaur skeleton from the Middle Jurassic of Scotland

The fossil record of dinosaurs in Scotland mostly comprises isolated highly fragmentary bones from the Great Estuarine Group in the Inner Hebrides (Bajocian–Bathonian). Here we report the first definite dinosaur body fossil ever found in Scotland (historically), having been discovered in 1973, but not collected until 45 years later. It is the first and most complete partial dinosaur skeleton currently known from Scotland. NMS G.2023.19.1 was recovered from a challenging foreshore location in the Isle of Skye, and transported to harbour in a semi-rigid inflatable boat towed by a motor boat. After manual preparation, micro-CT scanning was carried out, but this did not aid in identification. Among many unidentifiable elements, a neural arch, two ribs and part of the ilium are described herein, and their features indicate that this was a cerapodan or ornithopod dinosaur. Histological thin sections of one of the ribs support this identification, indicating an individual at least eight years of age, growing slowly at the time of death. If ornithopodan, as our data suggest, it could represent the world's oldest body fossil of this clade.

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Open Access

Greenhouse gases reduce the satellite carrying capacity of low Earth orbit

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