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      INFRAFRONTIER – the European Research Infrastructure for Modelling Human Diseases

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      conference-abstract
      1 , 1 , 1 , 2
      REPO4EU
      RExPO24
      3-5 July 2024
      Research Infrastructure, disease models, in-vivo models, in-vitro models, animal welfare, drug repurposing
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            Abstract

            INFRAFRONTIER, is a non-profit organisation dedicated to advancing the understanding and the treatment of human diseases through state-of-the-art in-vivo and in-vitro models. Comprised of a network of over 20 cutting-edge biomedical research institutes across Europe and beyond, it enables the generation, phenotyping, archiving, and distribution of advanced mouse and rat models as well as derived in-vitro model systems and associated FAIR data resources. Moreover, INFRAFRONTIER offers the generation of germ-free animals for axenic and gnotobiotic experimentation in biomedical research.

            Operating the largest mouse repository in Europe and one of the largest worldwide, INFRAFRONTIER empowers academia and industry scientists to accelerate their research on human health and disease. Committed to excellence, it adheres to rigorous scientific benchmarks and applies standardised protocols that prioritise animal welfare contributing to the refinement, reduction, and replacement of animal models. Furthermore, its collaboration with other European research infrastructures allows INFRAFRONTIER to contribute to the global sharing of FAIR research data and the provision of remote services. This collaboration creates a more interconnected European research community capable of reacting quickly, decisively and cooperatively to significant health challenges.

            Starting in June 2024, the INFRAPLUS project, recently selected for funding by the European Commission, will further enhance INFRAFRONTIER’s capabilities by expanding human disease modelling, reducing animal usage, and developing alternative cellular models. Building on these strengths of disease model generation, characterisation and validation, collaborative research and data sharing and data integration, INFRAFRONTIER can make a significant contribution to the field of drug repurposing in Europe and beyond.

            Content

            Author and article information

            Conference
            REPO4EU
            28 May 2024
            Affiliations
            [1 ] INFRAFRONTIER GmbH, München (Germany) ( https://ror.org/00vawn972)
            [2 ] Helmholtz Zentrum, München (Germany) ( https://ror.org/00cfam450)
            Author information
            https://orcid.org/0000-0002-8759-1186
            https://orcid.org/0000-0001-5411-7560
            https://orcid.org/0000-0002-7898-2353
            Article
            10.58647/REXPO.24005
            682b4055-d06c-4cf9-8408-6ef8837ce882
            The Authors

            Published under Creative Commons Attribution 4.0 International ( CC BY 4.0). Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source.

            RExPO24
            3
            Munich, Germany
            3-5 July 2024
            History
            Product

            REPO4EU

            Categories

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Pharmacology & Pharmaceutical medicine
            Research Infrastructure,disease models,in-vivo models,in-vitro models,animal welfare,drug repurposing

            References

            1. Ali Khan Asrar, Valera Vazquez Gema, Gustems Montse, Matteoni Rafaele, Song Fei, Gormanns Philipp, Fessele Sabine, Raess Michael, Hrabĕ de Angelis Martin. INFRAFRONTIER: mouse model resources for modelling human diseases. Mammalian Genome. Vol. 34(3):408–417. 2023. Springer Science and Business Media LLC. [Cross Ref]

            2. Ehlich Hilke, Cater Heather L., Flenniken Ann M., Goncalves Da Cruz Isabelle, Mura Anne-Marie, Ntafis Vasileios, Raess Michael, Selloum Mohammed, Stoeger Claudia, Suchanova Sarka, Vuolteenaho Reetta, Brown Steve D. M., Hérault Yann, Hinttala Reetta, Hrabě de Angelis Martin, Kollias George, Kontoyiannis Dimitris L., Malissen Bernard, McKerlie Colin, Sedláček Radislav, Wells Sara E., Zarubica Ana, Rozman Jan, Sorg Tania. INFRAFRONTIER quality principles in systemic phenotyping. Mammalian Genome. Vol. 33(1):120–122. 2022. Springer Science and Business Media LLC. [Cross Ref]

            3. Raess Michael, de Castro Ana Ambrosio, Gailus-Durner Valérie, Fessele Sabine, Hrabě de Angelis Martin. INFRAFRONTIER: a European resource for studying the functional basis of human disease. Mammalian Genome. Vol. 27(7-8):445–450. 2016. Springer Science and Business Media LLC. [Cross Ref]

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