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      Standard references for cellular models for pandemic preparedness

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      conference-abstract
        1 , , 2
      RExPO24 Conference
      REPO4EU
      RExPO24
      3-5 July 2024
      Cellular models, infectious diseases, 2D/3D culture, pandemic preparedness, platform
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            Abstract

            In the perspective of pandemic preparedness, within REPO4EU we aim to contribute to the development of a European platform including an element providing standard references for cellular models for infectious diseases. The need of this resource became more evident during the COVID-19 pandemic and follow-up studies, for which already approved drugs were tested for their efficacy against SARS-CoV-2 1. Among the limitations of drug repurposing for infectious diseases is the choice of the cellular models for functional and structural in vitro assays, which are influenced by several factors, like cellular tropism, expression of cellular receptor, mechanism of viral entry, cellular susceptibility and permissibility to the viral infection 2. All this information will be collected for cellular models including immortalized cell lines, primary and iPSC cells for 2D and 3D cultures and used to create reference standards. The contribution of the scientific community working on infectious diseases will be key to obtain a comprehensive list of cellular models. This resource will be implemented on an online platform including cellular models for the study of other diseases, resulting in a powerful scientific infrastructure.

            Content

            Author and article information

            Conference
            RExPO24 Conference
            REPO4EU
            3 May 2024
            Affiliations
            [1 ] Universität Hamburg, Centre for Structural Systems Biology (CSSB), Hamburg, Germany;
            [2 ] Universität Hamburg, Leibniz Institute of Virology (LIV), Centre for Structural Systems Biology (CSSB), Hamburg, Germany;
            Author notes
            Author information
            https://orcid.org/0009-0003-5786-6833
            https://orcid.org/0000-0002-4788-2691
            Article
            10.58647/REXPO.24000047.v1
            1baa50f6-d7b5-4955-9477-96bd380cdfba

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            RExPO24
            3
            Munich, Germany
            3-5 July 2024
            History
            : 3 May 2024
            Categories

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Cell biology,Biochemistry,Microbiology & Virology
            Cellular models, infectious diseases, 2D/3D culture, pandemic preparedness, platform

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