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      Chemogenomic screening in patient-derived tissue models enables target identification and drug repurposing

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      conference-abstract
      1 , 2 , 3
      REPO4EU
      RExPO23
      25-26 October 2023
      3D human tissue models, translational pharmacology, precision drug development
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            Abstract

            The number of successful drug development projects has been stagnant for decades despite major breakthroughs in chemistry, molecular biology and genomics. Unreliable translatability of preclinical in vitro and in vivo models has been identified as the cause of most failure. Organotypic and microphysiological culture of primary human cells has emerged as a set of promising tools for preclinical drug development to narrow this translation gap. In this talk I will provide an overview of our recent efforts in developing 3D human tissue cultures and microfluidic models for both efficacy and safety assessments. In addition, the talk will present recent use cases where such organotypic cultures identified new drug targets and had direct impacts on market authorizations.

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            Author and article information

            Conference
            REPO4EU
            4 October 2023
            Affiliations
            [1 ] Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm (Sweden) ( https://ror.org/056d84691)
            [2 ] Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Germany) ( https://ror.org/02pnjnj33)
            [3 ] University of Tübingen, Tübingen (Germany) ( https://ror.org/03a1kwz48)
            Author information
            https://orcid.org/0000-0002-1140-6204
            Article
            10.58647/REXPO.23017
            add6b1a1-68c2-4670-9516-e490c268e518
            Authors

            Published under Creative Commons Attribution 4.0 International ( CC BY 4.0). Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source.

            RExPO23
            2
            Stockholm, Sweden
            25-26 October 2023
            History
            Product

            REPO4EU

            Categories

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Pharmacology & Pharmaceutical medicine
            3D human tissue models,translational pharmacology,precision drug development

            References

            1. Stebbing Justin, Lauschke Volker M.. JAK Inhibitors — More Than Just Glucocorticoids. New England Journal of Medicine. Vol. 385(5):463–465. 2021. Massachusetts Medical Society. [Cross Ref]

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