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      Philanthropy’s Role in Catalyzing New Uses for Approved Treatments

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      conference-abstract
      1 , 1
      REPO4EU
      RExPO23
      25-26 October 2023
      Clinical trials, drug repurposing, repurposing, nonprofit, philanthropy, patient impact, off-label
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            Abstract

            Foundations, nonprofits, NGOs and other philanthropic organizations are frequently involved in supporting drug development. Cures Within Reach, a US-based nonprofit leader of testing already approved therapies for new indications in unsolved diseases, has been providing seed funds for first-in-human clinical trials for over 15 years. Philanthropy plays a critical role in risk mitigation of investigator-initiated trials, funding proof-of-concept, pivotal clinical trials as well as later-stage trials. Efforts such as these are complementary to the pharmaceutical industry’s portfolio life cycle management and complementary to governments’ funding of translational medicine initiatives. Results from smaller, earlier trials provide the data needed for industry, government agencies and others to fund the larger confirmatory trials. Together, these data build evidence for publication, allow clinicians to make their own decisions with their patients (off-label use) or for regulatory approval by the regulatory agencies. In addition, these efforts are not a question of commercial opportunity via intellectual property vs. charity, as these are not mutually exclusive – and often are not yet clearly known at earlier clinical trial stages.

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            Author and article information

            Conference
            REPO4EU
            27 September 2023
            Affiliations
            [1 ] Cures Within Reach, Chicago, Illinois, (USA) ( https://ror.org/0450ebe61)
            Article
            10.58647/REXPO.23013
            76dca083-50f4-4955-9cb3-cacb9db27102
            Authors

            Published under Creative Commons Attribution 4.0 International ( CC BY 4.0). Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source.

            RExPO23
            2
            Stockholm, Sweden
            25-26 October 2023
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            REPO4EU

            Categories

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Pharmacology & Pharmaceutical medicine
            Clinical trials,drug repurposing,repurposing,nonprofit,philanthropy,patient impact,off-label

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