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      Molecular sub-typing driven drug repurposing in oncology

      Published
      conference-abstract
      1
      REPO4EU
      RExPO23
      25-26 October 2023
      Cancer, NGS, Bioinformatics, Repurposing, Exome, Transcriptome, Omics, Sub-Typing, Modules, Stratification
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            Abstract

            Sub-typing in oncology has led to a substantial improvement in diagnosis and treatment of many forms of cancer such as breast cancer. Disease characterization in general and cancer diagnosis in particular still suffers from a sometimes-impeding classification based on body localization or mere list of symptoms. The utilization of multiomics data enables researchers to discern the underlying biology of diseases in line with the module system and allows for a more correct classification of different cancer indications based on their molecular signature.

            The sub-typing on these modules and signatures not only allows to group different organ origins together (e.g. CRC and NSCLC sub-types), it plays a major role in identifying drugs that target specifically the inherent mechanisms. Altogether, the utilization of a small number of highly specific biomarkers enables the identification of patient groups that highly benefits from certain drugs. Development of new drugs for such molecular modules and signatures is only partially necessary as already approved drugs might potentially target exactly those mechanisms and protein structures.

            Although sub-typing in cancer research holds great promise, it still has a long way to go before becoming routine practice. Examples from classically repurposed drugs (such as simvastatin and metformin) as well as lesser-known candidates (such as captopril, pioglitazone and isotretionin) will be given to illustrate the vast potential of this approach.

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            Author and article information

            Conference
            REPO4EU
            12 September 2023
            Affiliations
            [1 ] GeneSurge GmbH, Munich (Germany);
            Author information
            https://orcid.org/0000-0001-7473-8321
            Article
            10.58647/REXPO.23005
            524ad645-ca1d-462c-adb6-68692ba3a524
            Authors

            Published under Creative Commons Attribution 4.0 International ( CC BY 4.0). Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source.

            RExPO23
            2
            Stockholm, Sweden
            25-26 October 2023
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            REPO4EU

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            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Pharmacology & Pharmaceutical medicine
            Cancer,NGS,Bioinformatics,Repurposing,Exome,Transcriptome,Omics,Sub-Typing,Modules,Stratification

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