Streamlining and generalizing network-based drug discovery with NeDRex and Drugst.One

NeDRex (Network-based Drug Repurposing Explorer) (Sadegh et al. 2021, 2022) is a network-based computational tool used for drug repurposing. The NeDRex database houses a rich collection of data on Protein-Protein and Drug-Protein (target) interactions and integrates diverse data sources. The outcome is a comprehensive knowledge graph, enabling researchers to delve deep into the intricacies of these interactions. NeDRex utilizes network-based algorithms to analyze and identify potential drug-disease associations by integrating various biological data sources, such as protein-protein interaction networks, gene expression data, and drug-target interactions. Equipped with a suite of algorithms and tools, NeDRex offers capabilities for module identification, drug ranking, and intricate connectivity search, all tailored to streamline the drug repurposing journey.

Drugst.One (Maier et al. 2023), on the other hand, emerges as a platform crafted to facilitate the integration and customization of interactive network visualizations in the fields of drug discovery and repurposing. A pivotal feature is the web plugin, which offers seamless integration into any webpage, thereby enhancing the scope of interactive drug-related visualizations.

In essence, both NeDRex and Drugst.One highlight the significance of robust tools in drug discovery. While NeDRex centers on the analytical side with its algorithms and tools for module identification and drug ranking, Drugst.One prioritizes the user experience, offering seamless navigation and interactive visualizations. Combined, they represent valuable resources in the field of drug discovery and repurposing, simplifying the process and optimizing research efforts.