Biosimulation-based target deconvolution of cancer metabolism

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Biosimulation-based target deconvolution of cancer metabolism

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Author(s): Mauro DiNuzzo ¹ ^, , Alessandro Scandurra ¹ , Marco Salvatore ¹

Publication date (Electronic preprint): 8 May 2024

Journal: RExPO24 Conference

Publisher: REPO4EU

Conference name: RExPO24

Conference date: 3-5 July 2024

Keywords: artificial intelligence, biological networks, cancer, combination therapy, disease understanding, drug repurposing, modeling and simulation, oncometabolites, systems biology, target deconvolution

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Author and article information

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Title: RExPO24 Conference

Publisher: REPO4EU

Publication date (Electronic preprint): 8 May 2024

Affiliations

[1 ] Netabolics SRL, Rome, Italy;

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[* ]Email: mauro@ 123456netabolics.ai .

Author information

Mauro DiNuzzo https://orcid.org/0000-0003-0181-5597

Marco Salvatore https://orcid.org/0000-0001-5775-0417

Article

DOI: 10.58647/REXPO.24000057.v1

SO-VID: f30a6b1d-1ce8-45e3-9f7a-4f9df2b3bb0f

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This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

Conference name: RExPO24

Conference number: 3

Conference location: Munich, Germany

Conference date: 3-5 July 2024

History

Date received : 3 May 2024

References

Wishart David. Metabolomics and the Multi-Omics View of Cancer. Metabolites. Vol. 12(2)2022. MDPI AG. [Cross Ref]
Hanahan Douglas, Weinberg Robert A.. Hallmarks of Cancer: The Next Generation. Cell. Vol. 144(5):646–674. 2011. Elsevier BV. [Cross Ref]
DiNuzzo Mauro. How artificial intelligence enables modeling and simulation of biological networks to accelerate drug discovery. Frontiers in Drug Discovery. Vol. 2:2022. Frontiers Media SA. [Cross Ref]
Reznik Ed, Luna Augustin, Aksoy Bülent Arman, Liu Eric Minwei, La Konnor, Ostrovnaya Irina, Creighton Chad J., Hakimi A. Ari, Sander Chris. A Landscape of Metabolic Variation across Tumor Types. Cell Systems. Vol. 6(3)2018. Elsevier BV. [Cross Ref]
Lee GaRyoung, Lee Sang Mi, Lee Sungyoung, Jeong Chang Wook, Song Hyojin, Lee Sang Yup, Yun Hongseok, Koh Youngil, Kim Hyun Uk. Prediction of metabolites associated with somatic mutations in cancers by using genome-scale metabolic models and mutation data. Genome Biology. Vol. 25(1)2024. Springer Science and Business Media LLC. [Cross Ref]
Sainero-Alcolado Lourdes, Liaño-Pons Judit, Ruiz-Pérez María Victoria, Arsenian-Henriksson Marie. Targeting mitochondrial metabolism for precision medicine in cancer. Cell Death & Differentiation. Vol. 29(7):1304–1317. 2022. Springer Science and Business Media LLC. [Cross Ref]

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[1] Wishart David. Metabolomics and the Multi-Omics View of Cancer. Metabolites. Vol. 12(2)2022. MDPI AG. [Cross Ref]

[2] Hanahan Douglas, Weinberg Robert A.. Hallmarks of Cancer: The Next Generation. Cell. Vol. 144(5):646–674. 2011. Elsevier BV. [Cross Ref]

[3] DiNuzzo Mauro. How artificial intelligence enables modeling and simulation of biological networks to accelerate drug discovery. Frontiers in Drug Discovery. Vol. 2:2022. Frontiers Media SA. [Cross Ref]

[4] Reznik Ed, Luna Augustin, Aksoy Bülent Arman, Liu Eric Minwei, La Konnor, Ostrovnaya Irina, Creighton Chad J., Hakimi A. Ari, Sander Chris. A Landscape of Metabolic Variation across Tumor Types. Cell Systems. Vol. 6(3)2018. Elsevier BV. [Cross Ref]

[5] Lee GaRyoung, Lee Sang Mi, Lee Sungyoung, Jeong Chang Wook, Song Hyojin, Lee Sang Yup, Yun Hongseok, Koh Youngil, Kim Hyun Uk. Prediction of metabolites associated with somatic mutations in cancers by using genome-scale metabolic models and mutation data. Genome Biology. Vol. 25(1)2024. Springer Science and Business Media LLC. [Cross Ref]

[6] Sainero-Alcolado Lourdes, Liaño-Pons Judit, Ruiz-Pérez María Victoria, Arsenian-Henriksson Marie. Targeting mitochondrial metabolism for precision medicine in cancer. Cell Death & Differentiation. Vol. 29(7):1304–1317. 2022. Springer Science and Business Media LLC. [Cross Ref]

Abstract submission is now open for RExPO25, the 4th International Conference on Systems Medicine, AI & Drug Repurposing. Submit your proposal for a talk or poster and join us in Barcelona, Spain, September 24-26, 2025.

Deadline for abstracts is June 30, 2025

Biosimulation-based target deconvolution of cancer metabolism

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Abstract submission is now open for RExPO25, the 4^th International Conference on Systems Medicine, AI & Drug Repurposing. Submit your proposal for a talk or poster and join us in Barcelona, Spain, September 24-26, 2025.