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      Biomarkers to diagnose endotypes

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      proceedings-article
        1 ,
      ScienceOpen
      RExPO22
      2-3 September, 2022
      biomarker, endotype, diagnostic, prognostic, predictive, response, companion diagnostic
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            Abstract

            Different types of biomarkers have been defined (1) and demonstrated to have a significant impact on personalized medicine and drug development (2). Precise diagnostic is the basis for successful medical treatment. As many diseases have subtypes with clearly different prognoses/progression and/or responses to a medical intervention, diagnostic biomarkers are used to detect or confirm presence of a disease or condition of interest or to identify individuals with a subtype of the disease. The likelihood of a future clinical event, disease recurrence or progression in an already identified group of patients is described by prognostic biomarkers and typically measured at the beginning of a medical intervention. Predictive biomarkers are used to identify patients who are more likely to respond to specific treatment and/or for participation in a controlled clinical trial. Response/pharmacodynamic biomarker indicate that an individual patient reacted to a pharmaceutical treatment or medical intervention. An endotype is a disease subtype, which is defined by a distinct pathophysiological mechanism (3). The identification of a disease endotype is closely related to the mechanism that is a cause of the disease. The use of biomarkers significantly increases the probability of success in different phases of a drug in development. The highest level of clinical validation of a diagnostic test is reached by approval as companion diagnostic (4). A companion diagnostic device has been demonstrated to be essential for the safe and effective use of a corresponding therapeutic product.

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            Author and article information

            Conference
            ScienceOpen
            29 July 2022
            Affiliations
            [1 ] Invicol, Berlin, Germany
            Author notes
            Author information
            https://orcid.org/0000-0002-5907-3779
            Article
            10.14293/S2199-1006.1.SOR-.PPPBHY8D.v1
            0fe37ac8-ba48-4911-a494-b88dceb82ae7

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            RExPO22
            Maastricht, Netherlands
            2-3 September, 2022
            History
            : 29 July 2022

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            companion diagnostic,diagnostic,biomarker,endotype,response,predictive,prognostic

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