D5.3 - Initial whitepaper on rational for a wet-lab technology platform for patient recruitment

Precision medicine takes patient characteristics and differences on the phenotypic, endotypic and molecular level into account. With the aim to find the right drug for the right patient at the right time, precise diagnosis becomes essential to determine the best treatment for an individual. Diagnostic tests play a crucial role in recruiting the right patients for innovative clinical trials by identifying patients who are most likely to benefit from a specific treatment and who have specific disease characteristics like a molecular mechanism that is being targeted in the trial. Our wet-lab technology platform for patient recruitment will support the identification of the right patients for innovative clinical trials and guide clinical decisions towards personalised treatments using mechanism-based diagnostics. Mechanism-based diagnostics are diagnostic tests that use the understanding of a disease's underlying biology or pathophysiology to identify the right patient for a targeted treatment. These mechanism-based biomarker tests are used to determine the presence or absence of specific disease-causing mechanisms, such as mutations, biochemical pathways, or cellular processes, which can guide treatment decisions