Review of 'Machine Learning and Artificial Intelligence in drug repurposing – challenges and perspectives'

This review covers the field of computationa repurposing from several perspectives, which make it particularly useful for people new to the field, and also for having a quite comprehensive and updated references section available in one article.

The details of each methodology cannot be explianed in this review, but the examples and figures provided in some of the paragraphs help in that direction.

A few typos that I found through the document are summarized / proposed changes below:

. AI-based tools leveraging deep learning and neural networks are particularly promising to, for instance, screen compounds, predict new drug-target combinations, and assess adverse, which can ultimately speed up the selection of existing targets and drugs for new applications [15] [16] [17].

Should it be adverse drug reactions?

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s. It stands to potentially save millions of dollars in the costs associated with running clinical trials by predicting the likelihood of drug approval for specific indications in advance.

I would change it to:

s. It stands to potentially reduce significantly the costs associated with running clinical trials, by predicting the likelihood of drug approval for specific indications in advance, so that clinical trial priorities could be established.

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The hope is that deep learning strategies will learn latent data structures

Should it be?:

The hope is that deep learning strategies will learn from latent data structures

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the move from repositioning molecules to positioning using these methods and they are now being used across the industrial and academic settings.

Should be:

the move from repositioning molecules to positioning using these methods is now more often used across the industrial and academic settings.

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has highlighted the direct gene to protein relationship

should be:

has highlighted that the direct gene to protein relationship

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cell machinery. Ranging

should be:

cell machinery, ranging

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RWD allows to real-time assessment

Should be:

RWD allows for real-time assessment

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setting up standardized method

should be:

setting up standardized methods

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