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    Review of 'Diagnostics for Repurposed Drugs'

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    5
    Diagnostics for Repurposed DrugsCrossref
    Overall a very well written and easily understood mini-review covering diagnostics of cancer.
    Average rating:
        Rated 5 of 5.
    Level of importance:
        Rated 5 of 5.
    Level of validity:
        Rated 5 of 5.
    Level of completeness:
        Rated 5 of 5.
    Level of comprehensibility:
        Rated 5 of 5.
    Competing interests:
    None

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    Diagnostics for Repurposed Drugs

    Precision Diagnostics is a prerequisite for Precision Medicine by enabling a characterization of diseases on a molecular level leading to mechanism-based treatment. Giving the right drug to the right patient at the right dose and at the right time requires novel biomarker signatures to stratify patients accordingly. Diagnostics play an essential role in the context of drug repurposing, where existing drugs are investigated and repurposed for a new therapeutic use. They are important to identify the eligible patient population for a repurposed drug. Diagnostics are extremely valuable in determining which patients are most likely to benefit from a specific treatment. This way the effectiveness of a drug or combination of drugs is significantly increased and the chance of potential adverse effects is reduced. In addition to precise diagnostics in the wet-lab, both the patient recruitment and avoidance of adverse events can currently be supported by artificial intelligence (AI) based on empirical data sets (Cai, T. et al., 2021, Syrowatka, A. et al., 2022).
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      Review information

      10.14293/S2199-1006.1.SOR-LIFE.ANIEAY.v1.RWKAQQ
      This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

      Molecular medicine,Molecular biology,Bioinformatics & Computational biology,Pharmacology & Pharmaceutical medicine
      artificial intelligence,biomarker,multi-omics,diagnostics,repurposed drugs,mechanism-based

      Review text

      This is very well writen and easily understood min-review focusing on the use of diagnosis to stratify patients with disease using molecular signature to ensure and improve efficacy of new drugs particularly through repurposing and AI. The focus is on cancer and acute kideny injury neither of which I am particualry expert on. The level of the review is suitable for the non-expert and is both infomrative and easy to read. I have no major comments to make.

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