Big-Data enabled Repurposing of Clopidogrel for Focal Segmental Glomerulosclerosis using Network Biology

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Big-Data enabled Repurposing of Clopidogrel for Focal Segmental Glomerulosclerosis using Network Biology

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Author(s): Christoph A. Gebeshuber ¹ , Lisa Daniel-Fischer ² , Heinz Regele ³ , Helga Schachner ³ , Christoph Aufricht ² , Matthias Ley ¹ , Seth L. Alper ⁴ , Rebecca Herzog ² , Klaus Kratochwill ⁵ ^, ² , Paul Perco ¹ ^, ⁶

Publication date (Electronic, pub): 6 October 2023

Publisher: REPO4EU

Conference name: RExPO23

Conference date: 25-26 October 2023

Keywords: FSGS, clopidogrel, network medicine, drug repositioning, drug screening

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Publisher: REPO4EU

Publication date (Electronic, pub): 6 October 2023

Affiliations

[1 ] Delta 4 GmbH, Vienna (Austria);

[2 ] Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna (Austria) ( https://ror.org/05n3x4p02)

[3 ] Division of Pathology, Medical University of Vienna, Vienna (Austria) ( https://ror.org/05n3x4p02)

[4 ] Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts (USA) ( https://ror.org/04drvxt59)

[5 ] Delta 4 GmbH, Vienna (Austria);;

[6 ] Department of Internal Medicine IV, Medical University of Innsbruck, Innsbruck, Austria ( https://ror.org/03pt86f80)

Author information

Christoph A. Gebeshuber https://orcid.org/0000-0003-3293-4572

Klaus Kratochwill https://orcid.org/0000-0003-0803-614X

Paul Perco https://orcid.org/0000-0003-2087-5691

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DOI: 10.58647/REXPO.23029

SO-VID: b334357c-9774-42bc-87be-14d6f78fcf61

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Published under Creative Commons Attribution 4.0 International ( CC BY 4.0). Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source.

Conference name: RExPO23

Conference number: 2

Conference location: Stockholm, Sweden

Conference date: 25-26 October 2023

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Gebeshuber Christoph A., Daniel-Fischer Lisa, Regele Heinz, Schachner Helga, Aufricht Christoph, Kornauth Christoph, Ley Matthias, Alper Seth L., Herzog Rebecca, Kratochwill Klaus, Perco Paul. Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis. Translational Research. Vol. 259:28–34. 2023. Elsevier BV. [Cross Ref]

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[1] Gebeshuber Christoph A., Daniel-Fischer Lisa, Regele Heinz, Schachner Helga, Aufricht Christoph, Kornauth Christoph, Ley Matthias, Alper Seth L., Herzog Rebecca, Kratochwill Klaus, Perco Paul. Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis. Translational Research. Vol. 259:28–34. 2023. Elsevier BV. [Cross Ref]

Big-Data enabled Repurposing of Clopidogrel for Focal Segmental Glomerulosclerosis using Network Biology

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