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      Kompendium der medikamentösen Schmerztherapie 

      Schmerztherapie mit Opioiden

      other
      Springer Vienna

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          Most cited references22

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          Pharmacologic treatment of cancer pain.

          M. Levy (1996)
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            Character of terminal illness in the advanced cancer patient: pain and other symptoms during the last four weeks of life.

            There is a great variability among advanced cancer patients in the experience of symptoms and their impact on life's activities. A subgroup of difficult patients particularly tax the clinical skills and compassion of practitioners. Although the need for information about these patients is evident, their characteristics have not been explored heretofore. We describe our experience with such patients, a group referred to the Supportive Care Program of the Pain Service at Memorial Sloan-Kettering Cancer Center. Prevalence of pain and other symptoms, patterns of opioid use and routes of drug administration, and the prevalence of suicidal ideation and requests for euthanasia are discussed.
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              The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers.

              1. The absolute bioavailability of morphine from oral aqueous solution, a controlled release oral tablet (MST-Continus) and a controlled release buccal tablet has been investigated in six healthy volunteers. 2. Analysis of plasma samples for morphine and its active metabolite morphine-6-glucuronide (M6G) was by means of a differential radioimmunoassay technique. Absolute bioavailability for morphine was estimated to be 23.9% after oral solution, 22.4% after MST-Continus and 18.7% after the buccal tablet. Maximum plasma morphine concentrations were seen at 45 min (oral solution), 2.5 h (MST) and 6 h (buccal). 3. There was no difference in the amount of M6G appearing in plasma after intravenous, oral or buccal administration but the mean ratio of AUCs for M6G: morphine in plasma after intravenous morphine was 2 : 1 compared with 11 : 1 after oral and buccal morphine.
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                Author and book information

                Book Chapter
                2000
                : 21-56
                10.1007/978-3-7091-3779-6_4
                47973b60-7f8a-4283-b56e-bd9f423bf389
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