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      Compartmental Models in Epidemiology

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      Springer Berlin Heidelberg

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          Network theory and SARS: predicting outbreak diversity

          Many infectious diseases spread through populations via the networks formed by physical contacts among individuals. The patterns of these contacts tend to be highly heterogeneous. Traditional “compartmental” modeling in epidemiology, however, assumes that population groups are fully mixed, that is, every individual has an equal chance of spreading the disease to every other. Applications of compartmental models to Severe Acute Respiratory Syndrome (SARS) resulted in estimates of the fundamental quantity called the basic reproductive number R 0 —the number of new cases of SARS resulting from a single initial case—above one, implying that, without public health intervention, most outbreaks should spark large-scale epidemics. Here we compare these predictions to the early epidemiology of SARS. We apply the methods of contact network epidemiology to illustrate that for a single value of R 0 , any two outbreaks, even in the same setting, may have very different epidemiological outcomes. We offer quantitative insight into the heterogeneity of SARS outbreaks worldwide, and illustrate the utility of this approach for assessing public health strategies.
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            Contributions to the Mathematical Theory of Epidemics. II. The Problem of Endemicity

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              Contributions to the Mathematical Theory of Epidemics. III. Further Studies of the Problem of Endemicity

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                Author and book information

                Book Chapter
                2008
                : 19-79
                10.1007/978-3-540-78911-6_2
                288a7fd0-2105-4e3e-bfdd-a9e4b4d73e99
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