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      Breakthrough COVID19 Infections after Vaccinations in Healthcare and Other Workers in a Chronic Care Medical Facility in New Delhi, India

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          Abstract

          Background and Aims

          Vaccinations are now open to all adults in India. However, spread of COVID19 infection continues unabated. We aimed to ascertain number of breakthrough infections after vaccinations in a chronic care, diabetes-centric healthcare facility.

          Methods

          We received rigorously maintained data of vaccinations, health status, symptoms of COVID19 & RT-PCR testing of all staff (doctors, nurses, paramedical workers, other staff) in our health care facility from January 16, 2021 till date.

          Results

          Out of 123 employees, 110 were vaccinated (Covaxin, 28, Covishield, 85). Second dose was completed in 107 (94.7%) and first dose in 6 persons (5.3%). Breakthrough infections occurred in 18 persons (15.9%), 17 of them had incurred it after the second dose. Except one (required hospitalization), all (94.5%) had mild COVID19 disease.

          Conclusions

          High prevalence of mild breakthrough infection is seen in our health care facility. Research in breakthrough infections in India should be extended to other institutions and community to obtain larger data.

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          COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges

          Rimesh Pal, Sanjay Bhadada, Anoop Misra (2021)
          Background and aims To summarize the available evidence on the use COVID-19 vaccines in patients with diabetes mellitus. Methods We performed a thorough literature search with regard to COVID-19 vaccines in patients with type 1 and type 2 diabetes mellitus. Results The novel coronavirus disease (COVID-19) tends to portend a poor prognosis in patients with diabetes mellitus (DM). Primary prevention remains the mainstay for mitigating the risks associated with COVID-19 in patients with DM. A significant step in primary prevention is timely vaccination. Routine vaccination against pneumococcal pneumonia, influenza, and hepatitis B is recommended in patients with DM with good efficacy and reasonable safety profile. With clinical data supporting a robust neutralizing antibody response in COVID-19 patients with DM, vaccination in individuals with DM is justified. In fact, as the burden of the disease is borne by people with DM, COVID-19 vaccination should be prioritized in individuals with DM. Multiple unresolved issues with regard to preferred vaccine type, vaccine efficacy and durability, frequency of administration, vaccination in children (<18 years) and pregnant/lactating women remain, and need to be addressed through future research. Conclusions Patients with type 1 and type 2 diabetes mellitus are at a high risk of poor prognosis with COVID-19 and vaccination should be prioritized in them. However, many unresolved issues with regard to COVID-19 vaccination need to be addressed through future research.
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            Postvaccination SARS-CoV-2 Infections Among Skilled Nursing Facility Residents and Staff Members — Chicago, Illinois, December 2020–March 2021

            Richard A. Teran, Kelly A. Walblay, Elizabeth Shane … (2021)
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              Vaccine breakthrough infections with SARS-CoV2 variants

              Hacisuleyman, E Hacisuleyman, C Hale … (2025)
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                Author and article information

                Journal
                Journal ID (nlm-ta): Diabetes Metab Syndr
                Journal ID (iso-abbrev): Diabetes Metab Syndr
                Title: Diabetes & Metabolic Syndrome
                Publisher: Diabetes India. Published by Elsevier Ltd.
                ISSN (Print): 1871-4021
                ISSN (Electronic): 1878-0334
                Publication date PMC-release: 3 May 2021
                Publication date (Electronic): 3 May 2021
                Affiliations
                [a ]Centre of Nutrition & Metabolic Research (C-NET), National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India
                [b ]Diabetes Foundation (India), SDA, New Delhi
                [c ]Fortis C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, Chirag Enclave, Nehru Place, New Delhi
                Author notes
                [∗ ]Corresponding author. Fortis C-DOC (Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology) B-16, Chirag Enclave, New Delhi-110048, India.
                Article
                Publisher Item ID: S1871-4021(21)00139-9
                DOI: 10.1016/j.dsx.2021.05.001
                PMC ID: 8091733
                PubMed ID: 33991805
                SO-VID: 667dc8d3-4c1b-4628-8552-ae5dc606343d
                Copyright © © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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