0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Quantitative relationships between elastic modulus of rod and biomechanical properties of transforaminal lumbar interbody fusion: a finite element analysis

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Currently, some novel rods with lower elastic modulus have the potential as alternatives to traditional titanium alloy rods in lumbar fusion. However, how the elastic modulus of the rod (rod-E) influences the biomechanical performance of lumbar interbody fusion remains unclear. This study aimed to explore the quantitative relationships between rod-E and the biomechanical performance of transforaminal lumbar interbody fusion (TLIF).

          Methods

          The intact finite element model of L1-S1 was constructed and validated. Then 12 TLIF models with rods of different elastic moduli (ranging from 1 GPa to 110 GPa with an interval of 10 GPa) were developed. The range of motion (ROM) of the fixed segment, mean strain of the bone graft, and maximum von Mises stresses on the cage, endplate, and posterior fixation system models were calculated. Finally, regression analysis was performed to establish functional relationships between rod-E and these indexes.

          Results

          Increasing rod-E decreased ROM of the fixed segment, mean strain of the bone grafts, and peak stresses on the cage and endplate, while increasing peak stress on the screw-rod system. When rod-E increased from 1 GPa to 10 GPa, ROM decreased by 10.4%–39.4%. Further increasing rod-E from 10 GPa to 110 GPa resulted in a 9.3%–17.4% reduction in ROM. The peak stresses on the posterior fixation system showed a nonlinear increase as the rod-E increased from 1 GPa to 110 GPa under most loading conditions. The R 2 values for all fitting curves ranged from 0.76 to 1.00.

          Conclusion

          The functional relationships between rod-E and the biomechanical properties of TLIF were constructed comprehensively. When the rod-E exceeds 10 GPa, further increases may not significantly improve stability, however, it may increase the risk of fixation failure. Therefore, a rod with an elastic modulus of approximately 10 GPa may provide optimal biomechanical properties for TLIF.

          Related collections

          Most cited references45

          • Record: found
          • Abstract: found
          • Article: not found

          Comparison of eight published static finite element models of the intact lumbar spine: predictive power of models improves when combined together.

          Finite element (FE) model studies have made important contributions to our understanding of functional biomechanics of the lumbar spine. However, if a model is used to answer clinical and biomechanical questions over a certain population, their inherently large inter-subject variability has to be considered. Current FE model studies, however, generally account only for a single distinct spinal geometry with one set of material properties. This raises questions concerning their predictive power, their range of results and on their agreement with in vitro and in vivo values. Eight well-established FE models of the lumbar spine (L1-5) of different research centers around the globe were subjected to pure and combined loading modes and compared to in vitro and in vivo measurements for intervertebral rotations, disc pressures and facet joint forces. Under pure moment loading, the predicted L1-5 rotations of almost all models fell within the reported in vitro ranges, and their median values differed on average by only 2° for flexion-extension, 1° for lateral bending and 5° for axial rotation. Predicted median facet joint forces and disc pressures were also in good agreement with published median in vitro values. However, the ranges of predictions were larger and exceeded those reported in vitro, especially for the facet joint forces. For all combined loading modes, except for flexion, predicted median segmental intervertebral rotations and disc pressures were in good agreement with measured in vivo values. In light of high inter-subject variability, the generalization of results of a single model to a population remains a concern. This study demonstrated that the pooled median of individual model results, similar to a probabilistic approach, can be used as an improved predictive tool in order to estimate the response of the lumbar spine. Copyright © 2014 Elsevier Ltd. All rights reserved.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Mechanical behavior of the human lumbar and lumbosacral spine as shown by three-dimensional load-displacement curves.

            The lumbar region is a frequent site of spinal disorders, including low-back pain, and of spinal trauma. Clinical studies have established that abnormal intervertebral motions occur in some patients who have low-back pain. A knowledge of normal spinal movements, with all of the inherent complexities, is needed as a baseline. The present study documents the complete three-dimensional elastic physical properties of each lumbar intervertebral level from the level between the first and second lumbar vertebrae through the level between the fifth lumbar and first sacral vertebrae. Nine whole fresh-frozen human cadaveric lumbar-spine specimens were used. Pure moments of flexion-extension, bilateral axial torque, and bilateral lateral bending were applied, and three-dimensional intervertebral motions were determined with use of stereophotogrammetry. The motions were presented in the form of a set of six load-displacement curves, quantitating intervertebral rotations and translations. The curves were found to be non-linear, and the motions were coupled. The ranges of motion were found to compare favorably with reported values from in vivo studies.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Biomechanical evaluation of an interspinous stabilizing device, Locker.

              A biomechanical study.
                Bookmark

                Author and article information

                Contributors
                URI : https://loop.frontiersin.org/people/1541311/overviewRole: Role:
                Role: Role:
                URI : https://loop.frontiersin.org/people/1456313/overviewRole: Role:
                Role: Role:
                Role: Role:
                URI : https://loop.frontiersin.org/people/2270388/overviewRole: Role:
                Role: Role: Role:
                URI : https://loop.frontiersin.org/people/2867446/overviewRole: Role: Role: Role:
                Journal
                Front Bioeng Biotechnol
                Front Bioeng Biotechnol
                Front. Bioeng. Biotechnol.
                Frontiers in Bioengineering and Biotechnology
                Frontiers Media S.A.
                2296-4185
                07 January 2025
                2024
                : 12
                : 1510597
                Affiliations
                [1] 1 Department of Orthopedics , Second Affiliated Hospital of Xi’an Jiaotong University , Xi’an, Shaanxi, China
                [2] 2 Department of Orthopedics , The First Hospital of Yulin , Yulin, Shaanxi, China
                [3] 3 Department of Orthopedics , Civil Aviation General Hospital , Beijing, China
                [4] 4 Anhui Polytechnic University , School of Mechanical and Automotive Engineering , Wuhu, Anhui, China
                [5] 5 Department of Orthopaedics and Traumatology , Beijing Hospital of Traditional Chinese Medicine , Capital Medical University , Beijing, China
                Author notes

                Edited by: Alexandros E. Tsouknidas, Boston University, United States

                Reviewed by: Giulia Pascoletti, Università degli Studi di Perugia, Italy

                Konstantinos Krommydas, University of Western Macedonia, Greece

                *Correspondence: Ting Zhang, xjtumed1@ 123456163.com ; Haopeng Li, lihaopeng666@ 123456mail.xjtu.edu.cn
                [ † ]

                These authors have contributed equally to this work and share first authorship

                Article
                1510597
                10.3389/fbioe.2024.1510597
                11752904
                39845378
                2f757064-615c-4678-8c9d-0a6559f04ac7
                Copyright © 2025 Li, Du, Cao, Lu, Sun, Wei, Li and Zhang.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 13 October 2024
                : 24 December 2024
                Funding
                The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This article was supported by the Key Research and Development Program of Shaanxi Province (2021SF-344).
                Categories
                Bioengineering and Biotechnology
                Original Research
                Custom metadata
                Biomechanics

                transforaminal lumbar interbody fusion,connecting rod,elastic modulus,finite element analysis,biomechanical performance

                Comments

                Comment on this article