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      How Can Health Technology Assessment Help in Addressing Challenges in Drug Repurposing: A Conceptual Framework

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            Abstract

            Drug repurposing faces various challenges that impede its success. We developed a framework outlining key challenges in drug repurposing to explore when and how health technology assessment (HTA) methods can address them. Based on 73 articles, an expert meeting, and seven semi-structured interviews, we identified 20 challenges across the categories of data access, research and development, collaboration, business case, regulatory, and legal challenges. Early incorporation of HTA methods including literature review, empirical research, stakeholder consultation, health economic evaluation, and uncertainty assessment can help address these challenges. HTA methods can assess the value proposition of repurposed drugs, inform further research, and ultimately help bring cost-effective repurposed drugs to patients.

            Content

            Author and article information

            Journal
            DrugRxiv
            REPO4EU
            2 February 2024
            Affiliations
            [1 ] Department of Clinical Epidemiology & Medical Technology Assessment (KEMTA), Maastricht University Medical Centre, Maastricht, The Netherlands;
            [2 ] Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands ;
            [3 ] Program On Regulation, Therapeutics, And Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA;
            Author notes
            Author information
            https://orcid.org/0000-0002-1090-1721
            Article
            10.58647/DRUGARXIV.PR000013.v1
            89521f04-ff39-4b68-bd29-fc4d2f9d03a2

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            History
            : 2 February 2024
            Funding
            Funded by: funder-id http://dx.doi.org/10.13039/501100000780, European Commission;
            Categories

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Health & Social care,Economics

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