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      Accelerating Drug Develoment: Unleashing the Power of Drug Repurposing

      Preprint
      In review
      research-article
        1 ,
      DrugRxiv
      REPO4EU
      drug repurposing, drug development, artificial intelligence, regulatory framework
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            Abstract

            Drug repurposing, also called drug repositioning, reprofiling or retasking, is the process of identifying a new use for an existing medicine/active substance outside the scope of the original indication(s). It includes new therapeutic uses for existing medicines, different formulations of the same medicine, and/or creating new combinations of medicines or medicines with medical devices.

            Drug repurposing has recently attracted much attention as it promises faster timelines, lower costs and less risk compared to new drug development.

            Content

            Author and article information

            Journal
            DrugRxiv
            REPO4EU
            30 April 2024
            Affiliations
            [1 ] Regulatory Affairs Department, 3D-PharmXchange, Tilburg, The Netherlands;
            Author notes
            Author information
            https://orcid.org/0009-0000-3034-956X
            Article
            10.58647/DRUGARXIV.PR000012.v1
            a6a0f61d-9c64-449e-879b-769c5ad21eb8

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            History
            : 30 April 2024
            Categories

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            General medicine,General life sciences,Medicine,Pharmaceutical chemistry,Artificial intelligence,Pharmacology & Pharmaceutical medicine,Public health
            drug repurposing,drug development,artificial intelligence,regulatory framework

            References

            1. Asker-Hagelberg Charlotte, Boran Tomas, Bouygues Christelle, Eskola Sini Marika, Helmle Laszlo, Hernández César, Houýez François, Lee Helen, Lingri Dimitra D., Louette Laurent, Meheus Lydie, Penninckx Wim, Stepniewska Beata. Repurposing of Medicines in the EU: Launch of a Pilot Framework. Frontiers in Medicine. Vol. 8:2022. Frontiers Media SA. [Cross Ref]

            2. Zhang Zhe, Zhou Li, Xie Na, Nice Edouard C., Zhang Tao, Cui Yongping, Huang Canhua. Overcoming cancer therapeutic bottleneck by drug repurposing. Signal Transduction and Targeted Therapy. Vol. 5(1)2020. Springer Science and Business Media LLC. [Cross Ref]

            3. Ahmed Faheem, Soomro Afaque Manzoor, Chethikkattuveli Salih Abdul Rahim, Samantasinghar Anupama, Asif Arun, Kang In Suk, Choi Kyung Hyun. A comprehensive review of artificial intelligence and network based approaches to drug repurposing in Covid-19. Biomedicine & Pharmacotherapy. Vol. 153:2022. Elsevier BV. [Cross Ref]

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