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      Philanthropy’s Role in Catalyzing New Uses for Approved Treatments

      Preprint
      In review
      research-article
        1 ,
      DrugRxiv
      REPO4EU
      repurposing, clinical trials, philanthropy
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            Abstract

            Foundations, nonprofits, NGOs and other philanthropic organizations are frequently involved in supporting drug development. Cures Within Reach, a US-based nonprofit leader of testing already approved therapies for new indications in unsolved diseases, has been providing seed funds for first-in-human clinical trials for over 15 years. Philanthropy plays a critical role in risk mitigation of investigator-initiated trials, funding proof-of-concept, pivotal clinical trials as well as later-stage trials. Efforts such as these are complementary to the pharmaceutical industry’s portfolio life cycle management and complementary to governments’ funding of translational medicine initiatives. Results from smaller, earlier trials provide the data needed for industry, government agencies and others to fund the larger confirmatory trials. Together, these data build evidence for publication, allow clinicians to make their own decisions with their patients (off-label use) or for regulatory approval by the regulatory agencies. In addition, these efforts are not a question of commercial opportunity via intellectual property vs. charity, as these are not mutually exclusive – and often are not yet clearly known at earlier clinical trial stages.

            Content

            Author and article information

            Journal
            DrugRxiv
            REPO4EU
            8 April 2024
            Affiliations
            [1 ] Cures Within Reach;
            Author notes
            Author information
            https://orcid.org/0009-0008-4437-4086
            Article
            10.58647/DRUGARXIV.PR000011.v1
            25691dc1-8898-49de-865d-b302de1df501

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            History
            : 8 April 2024
            Funding
            Funded by: funder-id http://dx.doi.org/10.13039/100016374, Cures Within Reach;
            Categories

            Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
            Medicine
            repurposing,clinical trials,philanthropy

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