Purpose : Perceived quality of life has partly been based on the evaluation of people's major categories of fundamental life needs. Thus, people's perception of their position in life in the context of the culture and value systems in which they live, as relates to their goals, expectations, standards, and concerns, is their perceived quality of life. The Vitamin model elucidates the analogy of the physiological relationship between vitamins and health thereby explaining how psychological vitamins affect perceived quality of life, based on the work environment, cultural determinism, and person-environment in this case. The need to evaluate how health personnel perceived quality of life would affect their productivity and the consequent effect on overall quality of life is apt. Methods : The researchwas a cross-sectional designwith 346 participants, who were selected by stratified random sampling, as the study sample. The assessment tool was the Health Personnel Perceived Quality of Life Scale which measures how healthcare professionals perceived their quality of life in relation to job demand and performance. Principal component analysis and multiple regressions were used, based on p<0.05. Results : Age (F (4,3694) =0.01), marital status (F (19,3678) =0.03); and ethnicity (F (2,3696) =0.01) had significant influence on perceived quality of life among health personnel. However, gender (F (5,3693) =0.59) and professional affiliation (F (6,3692) =0.62) were not significant. Conclusion : The study concluded that quality of life perception among health personnel is influenced by their age level, marital status, and ethnicity, as mediated and or moderated by work environment andcultural determinism. Hence, the vitamin model analogy indicates a cogent need for the improved work environment, cultural determinism, and person-environment to ensure an improved quality of life. There is a need for more empirical studies, using the vitamin model analogy, towards improving the health personnel's perceived quality of life.