This study explores the interconnection between digital literacy, affective tendencies, gender dynamics, and library anxiety among college students in Greater Houston, Texas, with implications to Human-Computer Interactions. Through a comprehensive analysis of these variables, the research aims to provide insights into the complex relationship shaping students' academic experiences. A quantitative research design was utilized to collect data on digital literacy skills, affective tendencies, gender identification, and library anxiety from college students in Greater Houston, Texas. Statistical analyses, including regression and mediation analyses, was conducted to examine the relationships between the variables of interest. Findings reveal distinct patterns in digital literacy skills, emotional responses, and library anxiety across gender lines, highlighting the need for targeted interventions to support diverse student needs. Understanding the complex relationship between these variables can inform the design of user interfaces and interactive systems that cater to the diverse needs and experiences of college students. Introduction: The digital age has revolutionized the landscape of education, presenting both opportunities and challenges for students in Greater Houston, Texas, and beyond. As technology continues to permeate every aspect of academic life, from research and collaboration to communication and assessment, the need for digital literacy has never been more pronounced. Digital literacy encompasses not only the technical skills required to navigate digital platforms and tools but also the critical thinking abilities to evaluate and synthesize information in an increasingly complex digital ecosystem.