Problem and purpose. Influence on the autonomic regulation of panic attack (PA) can lead to the development of somatic diseases or aggravation of existing ones, which is a serious medical and social problem.

The purpose of this scientific review is to study the neurobiology of stress and fear, generalize the conceptual views of panic attacks and their relationship with cardiovascular diseases to create a further strategy for clinical trials of PA and optimize preventive and therapeutic measures.

Methodology. Six medical electronic databases (foreign and domestic) were searched from inception until 2022, including original research for the last five years, on anxiety disorders, PA, cardiovascular disease (CVD), the neurobiology of stress, non-specific protective-adaptive mechanisms and responses (NPAM&R) of human. As a methodological base, the author used a dialectical and systematic approach to achieve the set goals.

When checking headings, abstracts and full texts, the author used the research method of analysis. Using the deductive method, he determined particular patterns of various concepts. In case of finding disagreements, he synthesized possible solutions.

Results: The performed analysis of works devoted to the different concepts of panic attacks etiology, the fear attacks neurobiology and the evolution of pathogenetic views on the relationship between PA and CVD made it possible to reveal the significant significance of the non-linear "mediator" effect in the development of PA and their influence on CVD.

In a result of the analysis and synthesis of data from different PA concepts, the author found that there are no contradictions between the concepts and proposes the PA concept with a wider range of non-linear "mediator" PA mechanism. By the obtained results, the author substantiates the relationship NPAM&R with PA and CVD using a non-linear "mediator" mechanism.

Conclusion: The study of NZPM&R is important for improving general physical and mental health and the well-being of the nation in the long term, especially in the face of aggressive environmental factors. It also allows us to emphasize the need to study complex methods of treatment, including "non-specific", the results of which should be reflected in the new standards of treatment for this nosology.