<b>Exploring Salicylate Derivatives of Naproxen as DHFR Inhibitors: </b> <b>A New Therapeutic Avenue in Cancer Treatment</b>

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Header Abstract Content Author and article information References Comments

Record: found
Abstract: found
Poster: found

Is Open Access

Exploring Salicylate Derivatives of Naproxen as DHFR Inhibitors: A New Therapeutic Avenue in Cancer Treatment

Published

poster

Author(s): Syon Schlecht ¹ ^, , Emily Gunderson ¹

Other contributor(s): Ruthie Fowler ¹ (Research-assistant), Takara Aguilar ¹ (Research-assistant)

Publication date (Electronic preprint): 1 May 2024

Journal: ScienceOpen Posters

Publisher: ScienceOpen

Keywords: Dihydrofolate reductase (DHFR), DHFR, Chemotherapy, Nonsteroidal anti-inflammatory drugs (NSAIDs), Folate metabolism pathway, Novel therapeutic development

Bookmark

Abstract

Content

Author and article information

Journal

Title: ScienceOpen Posters

Publisher: ScienceOpen

Publication date (Electronic preprint): 1 May 2024

Affiliations

[1 ] Empower College and Career Center;

Author notes

[* ]Email: director@ 123456syonlabs.org .

Author information

Syon Schlecht https://orcid.org/0000-0001-6177-6150

Article

DOI: 10.14293/P2199-8442.1.SOP-.PWB2BX.v1

SO-VID: 5c448350-3132-4308-9579-6ac88ae8fd93

License:

This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

History

Date received : 1 May 2024

References

Duff Michael R., Gabel Scott A., Pedersen Lars C., DeRose Eugene F., Krahn Juno M., Howell Elizabeth E., London Robert E.. The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. Journal of Medicinal Chemistry. Vol. 63(15):8314–8324. 2020. American Chemical Society (ACS). [Cross Ref]
Selhub Jacob, Dhar G. Jeelani, Rosenberg Irwin H.. Inhibition of Folate Enzymes by Sulfasalazine. Journal of Clinical Investigation. Vol. 61(1):221–224. 1978. American Society for Clinical Investigation. [Cross Ref]
Bowden K, Hall A D, Birdsall B, Feeney J, Roberts G C K. Interactions between inhibitors of dihydrofolate reductase. Biochemical Journal. Vol. 258(2):335–342. 1989. Portland Press Ltd. [Cross Ref]

Comments

Comment on this article

[1] Duff Michael R., Gabel Scott A., Pedersen Lars C., DeRose Eugene F., Krahn Juno M., Howell Elizabeth E., London Robert E.. The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. Journal of Medicinal Chemistry. Vol. 63(15):8314–8324. 2020. American Chemical Society (ACS). [Cross Ref]

[2] Selhub Jacob, Dhar G. Jeelani, Rosenberg Irwin H.. Inhibition of Folate Enzymes by Sulfasalazine. Journal of Clinical Investigation. Vol. 61(1):221–224. 1978. American Society for Clinical Investigation. [Cross Ref]

[3] Bowden K, Hall A D, Birdsall B, Feeney J, Roberts G C K. Interactions between inhibitors of dihydrofolate reductase. Biochemical Journal. Vol. 258(2):335–342. 1989. Portland Press Ltd. [Cross Ref]