Manipulating the Manipulator: Genetically modifying  <i>T. gondii</i> to degrade rather than produce dopamine could be used to treat symptoms of schizophrenia

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Manipulating the Manipulator: Genetically modifying T. gondii to degrade rather than produce dopamine could be used to treat symptoms of schizophrenia

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Author(s): Asna Rasuli ¹ ^, , Simran Mody ¹ , Ayobola Akanni ¹ , Xuerui Hu ¹ , Haricharan Chandran ¹ , Krazelle Clemente ¹ , Jun Chen ¹

Publication date (Electronic preprint): 30 March 2023

Journal: ScienceOpen Posters

Publisher: ScienceOpen

Keywords: Dopamine, Toxoplasma gondii, toxoplasmosis, COMT, tyrosine hydroxylase

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Abstract

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Author and article information

Journal

Title: ScienceOpen Posters

Publisher: ScienceOpen

Publication date (Electronic preprint): 30 March 2023

Affiliations

[1 ] University of Toronto ( https://ror.org/03dbr7087)

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[* ]Email: Asna.rasuli@ 123456gmail.com .

Author information

Asna Rasuli https://orcid.org/0009-0006-7749-9956

Article

DOI: 10.14293/P2199-8442.1.SOP-.PDKFYU.v1

SO-VID: 5db39432-74bd-4b3b-915b-e0e1f10ef179

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This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

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Date received : 30 March 2023

References

Brisch Ralf, Saniotis Arthur, Wolf Rainer, Bielau Hendrik, Bernstein Hans-Gert, Steiner Johann, Bogerts Bernhard, Braun Anna Katharina, Jankowski Zbigniew, Kumaritlake Jaliya, Henneberg Maciej, Gos Tomasz. The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue. Frontiers in Psychiatry. Vol. 5:2014. Frontiers Media SA. [Cross Ref]
Flegr Jaroslav, Preiss Marek, Klose Jiřı́, Havlı́ček Jan, Vitáková Martina, Kodym Petr. Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii Dopamine, a missing link between schizophrenia and toxoplasmosis? Biological Psychology. Vol. 63(3):253–268. 2003. Elsevier BV. [Cross Ref]
Gaskell Elizabeth A., Smith Judith E., Pinney John W., Westhead Dave R., McConkey Glenn A.. A Unique Dual Activity Amino Acid Hydroxylase in Toxoplasma gondii. PLoS ONE. Vol. 4(3)2009. Public Library of Science (PLoS). [Cross Ref]
Herken Hasan, Emin Erdal M.. Catechol-O -methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis. Psychiatric Genetics. Vol. 11(2):105–109. 2001. Ovid Technologies (Wolters Kluwer Health). [Cross Ref]
Poulin Robert, Levri Edward P.. Applied aspects of host manipulation by parasitesHost Manipulation by Parasites. p. 172–194. 2012. Oxford University Press. [Cross Ref]
Nath Avindra, Sinai Anthony P.. Cerebral toxoplasmosis. Current Treatment Options in Neurology. Vol. 5(1):3–12. 2003. Springer Science and Business Media LLC. [Cross Ref]
Prandovszky Emese, Gaskell Elizabeth, Martin Heather, Dubey J. P., Webster Joanne P., McConkey Glenn A.. The Neurotropic Parasite Toxoplasma Gondii Increases Dopamine Metabolism. PLoS ONE. Vol. 6(9)2011. Public Library of Science (PLoS). [Cross Ref]
Ru Wenzhao, Fang Pengpeng, Wang Bei, Yang Xing, Zhu Xu, Xue Mengying, Shen Guomin, Gao Xiaocai, Gong Pingyuan. The impacts of Val158Met in Catechol-O-methyltransferase (COMT) gene on moral permissibility and empathic concern. Personality and Individual Differences. Vol. 106:52–56. 2017. Elsevier BV. [Cross Ref]
Rubí Blanca, Maechler Pierre. Minireview: New Roles for Peripheral Dopamine on Metabolic Control and Tumor Growth: Let’s Seek the Balance. Endocrinology. Vol. 151(12):5570–5581. 2010. The Endocrine Society. [Cross Ref]
Schaeffer Scott M., Nakata Paul A.. CRISPR/Cas9-mediated genome editing and gene replacement in plants: Transitioning from lab to field. Plant Science. Vol. 240:130–142. 2015. Elsevier BV. [Cross Ref]
Serretti Alessandro, Ronchi Diana, Lorenzi Cristina, Berardi Domenico. New Antipsychotics and Schizophrenia: A Review on Efficacy and Side Effects. Current Medicinal Chemistry. Vol. 11(3):343–358. 2004. Bentham Science Publishers Ltd. [Cross Ref]
Stock Ann-Kathrin, Heintschel von Heinegg Evelyn, Köhling Hedda-Luise, Beste Christian. Latent Toxoplasma gondii infection leads to improved action control. Brain, Behavior, and Immunity. Vol. 37:103–108. 2014. Elsevier BV. [Cross Ref]
Yin Kun, Xu Chao, Zhao Guihua, Xie Huanhuan. Epigenetic Manipulation of Psychiatric Behavioral Disorders Induced by Toxoplasma gondii. Frontiers in Cellular and Infection Microbiology. Vol. 12:2022. Frontiers Media SA. [Cross Ref]

Comments

Comment on this article

[1] Brisch Ralf, Saniotis Arthur, Wolf Rainer, Bielau Hendrik, Bernstein Hans-Gert, Steiner Johann, Bogerts Bernhard, Braun Anna Katharina, Jankowski Zbigniew, Kumaritlake Jaliya, Henneberg Maciej, Gos Tomasz. The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue. Frontiers in Psychiatry. Vol. 5:2014. Frontiers Media SA. [Cross Ref]

[2] Flegr Jaroslav, Preiss Marek, Klose Jiřı́, Havlı́ček Jan, Vitáková Martina, Kodym Petr. Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii Dopamine, a missing link between schizophrenia and toxoplasmosis? Biological Psychology. Vol. 63(3):253–268. 2003. Elsevier BV. [Cross Ref]

[3] Gaskell Elizabeth A., Smith Judith E., Pinney John W., Westhead Dave R., McConkey Glenn A.. A Unique Dual Activity Amino Acid Hydroxylase in Toxoplasma gondii. PLoS ONE. Vol. 4(3)2009. Public Library of Science (PLoS). [Cross Ref]

[4] Herken Hasan, Emin Erdal M.. Catechol-O -methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis. Psychiatric Genetics. Vol. 11(2):105–109. 2001. Ovid Technologies (Wolters Kluwer Health). [Cross Ref]

[5] Poulin Robert, Levri Edward P.. Applied aspects of host manipulation by parasitesHost Manipulation by Parasites. p. 172–194. 2012. Oxford University Press. [Cross Ref]

[6] Nath Avindra, Sinai Anthony P.. Cerebral toxoplasmosis. Current Treatment Options in Neurology. Vol. 5(1):3–12. 2003. Springer Science and Business Media LLC. [Cross Ref]

[7] Prandovszky Emese, Gaskell Elizabeth, Martin Heather, Dubey J. P., Webster Joanne P., McConkey Glenn A.. The Neurotropic Parasite Toxoplasma Gondii Increases Dopamine Metabolism. PLoS ONE. Vol. 6(9)2011. Public Library of Science (PLoS). [Cross Ref]

[8] Ru Wenzhao, Fang Pengpeng, Wang Bei, Yang Xing, Zhu Xu, Xue Mengying, Shen Guomin, Gao Xiaocai, Gong Pingyuan. The impacts of Val158Met in Catechol-O-methyltransferase (COMT) gene on moral permissibility and empathic concern. Personality and Individual Differences. Vol. 106:52–56. 2017. Elsevier BV. [Cross Ref]

[9] Rubí Blanca, Maechler Pierre. Minireview: New Roles for Peripheral Dopamine on Metabolic Control and Tumor Growth: Let’s Seek the Balance. Endocrinology. Vol. 151(12):5570–5581. 2010. The Endocrine Society. [Cross Ref]

[10] Schaeffer Scott M., Nakata Paul A.. CRISPR/Cas9-mediated genome editing and gene replacement in plants: Transitioning from lab to field. Plant Science. Vol. 240:130–142. 2015. Elsevier BV. [Cross Ref]

[11] Serretti Alessandro, Ronchi Diana, Lorenzi Cristina, Berardi Domenico. New Antipsychotics and Schizophrenia: A Review on Efficacy and Side Effects. Current Medicinal Chemistry. Vol. 11(3):343–358. 2004. Bentham Science Publishers Ltd. [Cross Ref]

[12] Stock Ann-Kathrin, Heintschel von Heinegg Evelyn, Köhling Hedda-Luise, Beste Christian. Latent Toxoplasma gondii infection leads to improved action control. Brain, Behavior, and Immunity. Vol. 37:103–108. 2014. Elsevier BV. [Cross Ref]

[13] Yin Kun, Xu Chao, Zhao Guihua, Xie Huanhuan. Epigenetic Manipulation of Psychiatric Behavioral Disorders Induced by Toxoplasma gondii. Frontiers in Cellular and Infection Microbiology. Vol. 12:2022. Frontiers Media SA. [Cross Ref]