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      Discerning the functional role of plasmalogen at the synapse by shotgun lipidomics

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            Abstract

            Content

            Author and article information

            Journal
            Title: ScienceOpen Posters
            Publisher: ScienceOpen
            Publication date (Electronic preprint): 31 May 2024
            Affiliations
            [1 ] Institute of Life Sciences 1, Singleton Campus, Swansea University, SA2 8PP ( https://ror.org/053fq8t95)
            [2 ] NMSF, Swansea University Medical School, Singleton Park, Swansea SA2 8PP ( https://ror.org/053fq8t95)
            Author notes
            Author information
            https://orcid.org/0009-0004-3758-2822
            https://orcid.org/0000-0002-9618-4785
            https://orcid.org/0000-0001-5136-5921
            Article
            DOI: 10.14293/P2199-8442.1.SOP-.PBAJDK.v1
            SO-VID: fb06fa2b-a92e-4fd0-8aeb-31ac78a6dc43
            License:

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            History
            Date received : 31 May 2024
            Funding
            Funded by: funder-id http://dx.doi.org/10.13039/501100000288, Royal Society;
            Funded by: funder-id http://dx.doi.org/10.13039/100010388, St. David's Medical Foundation;
            Funded by: funder-id http://dx.doi.org/10.13039/501100000691, Academy of Medical Sciences;
            Categories

            Data availability: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
            ScienceOpen disciplines: Cell biology,Biochemistry,Molecular biology,Neurosciences,Analytical chemistry
            Keywords: Neuroscience,Synapse,Neurodegeneration,Lipidomics,Plasmalogen

            References

            1. Braverman Nancy E., Moser Ann B.. Functions of plasmalogen lipids in health and disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. Vol. 1822(9):1442–1452. 2012. Elsevier BV. [Cross Ref]

            2. Murphy Robert C.. Free-Radical-Induced Oxidation of Arachidonoyl Plasmalogen Phospholipids:  Antioxidant Mechanism and Precursor Pathway for Bioactive Eicosanoids. Chemical Research in Toxicology. Vol. 14(5):463–472. 2001. American Chemical Society (ACS). [Cross Ref]

            3. Bozelli José Carlos, Epand Richard M.. Plasmalogen Replacement Therapy. Membranes. Vol. 11(11)2021. MDPI AG. [Cross Ref]

            4. Dravid Anusha, Raos Brad, Svirskis Darren, O’Carroll Simon J.. Optimised techniques for high-throughput screening of differentiated SH-SY5Y cells and application for neurite outgrowth assays. Scientific Reports. Vol. 11(1)2021. Springer Science and Business Media LLC. [Cross Ref]

            5. Wood Paul L. Lipidomics of Alzheimer's disease: current status. Alzheimer's Research & Therapy. Vol. 4(1)2012. Springer Science and Business Media LLC. [Cross Ref]

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