Structural landscape of SARS-CoV-2 entry and activation of spike glycoprotein by engaging unique host factors &amp; potential interventions

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Structural landscape of SARS-CoV-2 entry and activation of spike glycoprotein by engaging unique host factors & potential interventions

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Author(s): Naveen Vankadari ¹ ^, , Mitnala Sasikala ² , Xuemin Fang ³ , Lu Tian ⁴ , Sabbu S Latha ⁵ , Peng Peng ⁷ , Nageshwar D Reddy ² , Debnath Ghosal ¹ , Jackie A Wilce ⁷

Publication date (Electronic): 21 January 2025

Conference name: 13th Asia Pacific Microscopy Congress 2025 (APMC13)

Conference date: 2-7 Febuary 2025

Keywords: Host factors, viral entry, antivirals, structure, molecular dynamics, genetic variants

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Author and article information

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Publication date (Electronic): 21 January 2025

Electronic Location Identifier: e396

Affiliations

[1 ]Bio21 Institute, University of Melbourne, Parkville, VIC, Australia

[2 ]Institute of Translational Research, AIG Hospital, Hyderabad, Telangana, India

[3 ]Graduate School of Health Innovation, Kanagawa University, Japan

[4 ]Department of Biomedical Data Science, Stanford University, California, CA, USA

[5 ]Center for Innovation in Molecular Sciences, Dr. Reddy's Institute, Hyderabad, India

[6 ]Wuhan Institute, Wuhan Pulmonary Hospital, Wuhan City, Hubei Province, China

[7 ]Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

Author notes

*Corresponding author: naveen.vankadari@ 123456unimelb.edu.au

Presenting Authors: Naveen Vankadari, e-mail: Naveen.vankadari@ 123456unimelb.edu.au

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DOI: 10.14293/APMC13-2025-0396

SO-VID: 5520bcff-b867-4b88-bfda-7b03c8e39f2f

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Published under Creative Commons Attribution 4.0 International ( CC BY 4.0). Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source.

Conference name: 13th Asia Pacific Microscopy Congress 2025

Conference acronym: APMC13

Conference number: 13

Conference location: Brisbane, Australia

Conference date: 2-7 Febuary 2025

History

References

R Verity et al., (2020), Lancet Infectious diseases
M Young et al., (2022), BMJ Medicine
N Vankadari et al., (2022), ACS. J. Phys. Chem Lett
N Vankadari & JA Wilce. (2020), Emerging Microbes & Infections
Jun Lan et al., (2020) Nature
N Vankadari, (2020), ACS. J. Phys. Chem Lett
Ravikanth V, Minta S & N Vankadari* et al., (2021), NEJM and GENE
N Vankadari et al., (2024), ACS J. Physical Chem Lett
Qibin L*, Xuemin F*, Lu T*, N Vankadari*.et al., (2021), MedRxiv
N Vankadari. (2020), Int. J. Antimicrobial Agent

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[1] R Verity et al., (2020), Lancet Infectious diseases

[2] M Young et al., (2022), BMJ Medicine

[3] N Vankadari et al., (2022), ACS. J. Phys. Chem Lett

[4] N Vankadari & JA Wilce. (2020), Emerging Microbes & Infections

[5] Jun Lan et al., (2020) Nature

[6] N Vankadari, (2020), ACS. J. Phys. Chem Lett

[7] Ravikanth V, Minta S & N Vankadari* et al., (2021), NEJM and GENE

[8] N Vankadari et al., (2024), ACS J. Physical Chem Lett

[9] Qibin L*, Xuemin F*, Lu T*, N Vankadari*.et al., (2021), MedRxiv

[10] N Vankadari. (2020), Int. J. Antimicrobial Agent