Ultrastructure Expansion Microscopy of blood-stage <i>Plasmodium falciparum</i> reveals precise localization of tight junction proteins during invasion

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Ultrastructure Expansion Microscopy of blood-stage Plasmodium falciparum reveals precise localization of tight junction proteins during invasion

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Author(s): Dawson B Ling ¹ ^, ² ^, , Cindy Evelyn ¹ ^, ² , Aurelie T Dawson ¹ ^, ² , Danushka S Marapana ¹ ^, ² , Alan F Cowman ¹ ^, ² , Niall D Geoghegan ¹ ^, ² , Kelly L Rogers ¹ ^, ²

Publication date (Electronic): 21 January 2025

Conference name: 13th Asia Pacific Microscopy Congress 2025 (APMC13)

Conference date: 2-7 Febuary 2025

Keywords: Expansion, Malaria, Biology, Light, Fluorescence

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Author and article information

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Publication date (Electronic): 21 January 2025

Electronic Location Identifier: e275

Affiliations

[1 ]The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

[2 ]Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

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*Corresponding author: ling.d@ 123456wehi.edu.au

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DOI: 10.14293/APMC13-2025-0275

SO-VID: f90bb118-42ca-4ce9-8c59-f025e2895935

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Published under Creative Commons Attribution 4.0 International ( CC BY 4.0). Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source.

Conference name: 13th Asia Pacific Microscopy Congress 2025

Conference acronym: APMC13

Conference number: 13

Conference location: Brisbane, Australia

Conference date: 2-7 Febuary 2025

History

References

World Health Organization (2023). World Malaria Report 2023. Geneva: World Health Organization.
Geoghegan ND et al. 4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation. Nat Commun. 2021 Jun 15;12(1):3620. doi: 10.1038/s41467-021-23626-7. PMID: 34131147; PMCID: PMC8206130.
Scally SW et al. PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum. Nat Microbiol. 2022 Dec;7(12):2039-2053. doi: 10.1038/s41564-022-01261-2. Epub 2022 Nov 17. PMID: 36396942; PMCID: PMC9712106.
Pulido-Quevedo FA et al. Plasmodium falciparum rhoptry neck protein 4 has conserved regions mediating interactions with receptors on human erythrocytes and hepatocyte membrane. Int J Med Microbiol. 2023 May;313(3):151579. doi: 10.1016/j.ijmm.2023.151579. Epub 2023 Apr 3. PMID: 37030083.
Angage D, et al. A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites. Nat Commun. 2024 Aug 22;15(1):7206. doi: 10.1038/s41467-024-50770-7. PMID: 39174515; PMCID: PMC11341838.
Aikawa M et al. Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite. J Cell Biol. 1978 Apr;77(1):72-82. doi: 10.1083/jcb.77.1.72. PMID: 96121; PMCID: PMC2110026.
Bannister LH et al. Ultrastructure of rhoptry development in Plasmodium falciparum erythrocytic schizonts. Parasitology. 2000 Sep;121 ( Pt 3):273-87. doi: 10.1017/s0031182099006320. PMID: 11085247.
Bannister LH et al. Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development. J Cell Sci. 2003 Sep 15;116(Pt 18):3825-34. doi: 10.1242/jcs.00665. Epub 2003 Aug 5. PMID: 12902400.

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[1] World Health Organization (2023). World Malaria Report 2023. Geneva: World Health Organization.

[2] Geoghegan ND et al. 4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation. Nat Commun. 2021 Jun 15;12(1):3620. doi: 10.1038/s41467-021-23626-7. PMID: 34131147; PMCID: PMC8206130.

[3] Scally SW et al. PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum. Nat Microbiol. 2022 Dec;7(12):2039-2053. doi: 10.1038/s41564-022-01261-2. Epub 2022 Nov 17. PMID: 36396942; PMCID: PMC9712106.

[4] Pulido-Quevedo FA et al. Plasmodium falciparum rhoptry neck protein 4 has conserved regions mediating interactions with receptors on human erythrocytes and hepatocyte membrane. Int J Med Microbiol. 2023 May;313(3):151579. doi: 10.1016/j.ijmm.2023.151579. Epub 2023 Apr 3. PMID: 37030083.

[5] Angage D, et al. A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites. Nat Commun. 2024 Aug 22;15(1):7206. doi: 10.1038/s41467-024-50770-7. PMID: 39174515; PMCID: PMC11341838.

[6] Aikawa M et al. Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite. J Cell Biol. 1978 Apr;77(1):72-82. doi: 10.1083/jcb.77.1.72. PMID: 96121; PMCID: PMC2110026.

[7] Bannister LH et al. Ultrastructure of rhoptry development in Plasmodium falciparum erythrocytic schizonts. Parasitology. 2000 Sep;121 ( Pt 3):273-87. doi: 10.1017/s0031182099006320. PMID: 11085247.

[8] Bannister LH et al. Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development. J Cell Sci. 2003 Sep 15;116(Pt 18):3825-34. doi: 10.1242/jcs.00665. Epub 2003 Aug 5. PMID: 12902400.