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      Process design for microbial plastic factories: metabolic engineering of polyhydroxyalkanoates.

      Current Opinion in Biotechnology
      Acyltransferases, biosynthesis, Bacteria, chemistry, metabolism, Biomedical Engineering, Microbiological Techniques, Plastics, Protein Engineering

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          Abstract

          Implementing several metabolic engineering strategies, either individually or in combination, it is possible to construct microbial plastic factories to produce a variety of polyhydroxyalkanoate (PHA) biopolymers with desirable structures and material properties. Approaches include external substrate manipulation, inhibitor addition, recombinant gene expression, host cell genome manipulation and, most recently, protein engineering of PHA biosynthetic enzymes. In addition, mathematical models and molecular methods can be used to elucidate metabolically engineered systems and to identify targets for performance improvement.

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          Author and article information

          Journal
          14580576
          10.1016/j.copbio.2003.09.002

          Chemistry
          Acyltransferases,biosynthesis,Bacteria,chemistry,metabolism,Biomedical Engineering,Microbiological Techniques,Plastics,Protein Engineering

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