16
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Nitric oxide (NO) has shown great potential in tumor therapy, and the development of a platform for precise and controllable NO release still needs to be explored. Herein, a microfluidic electrospray strategy is proposed for the fabrication of hydrogel microspheres encapsulating NO donors (S‐nitrosoglutathione, GSNO) together with black phosphorus (BP) and chemotherapeutic doxorubicin (DOX) as microcarriers for tumor therapy. Based on the excellent photothermal property of BP and thermal sensitivity of GSNO, the microcarriers exhibit a near‐infrared light (NIR)‐responsive NO release behavior. Besides, the photothermal performance of the microcarriers accelerates the release of DOX. All these contribute to the excellent tumor‐killing effect of the microcarriers by combining multiple therapeutic strategies including NO therapy, photothermal therapy, and chemotherapy. Moreover, it was demonstrated that the NIR‐responsive NO delivery microcarriers could significantly inhibit tumor growth without apparent side effects in vivo. Therefore, it is believed that the novel NIR‐responsive NO microcarriers are promising candidates in clinical tumor therapy applications.

          Abstract

          Schematic illustration of the preparation of the NIR‐responsive NO microcarriers loaded with black phosphorus (BP), NO donors (GSNO) and DOX and the localized delivery of the microcarriers for multimodal tumor therapy.

          Related collections

          Author and article information

          Contributors
          luoranshang@fudan.edu.cn
          fame198288@126.com
          Journal
          Smart Med
          Smart Med
          10.1002/(ISSN)2751-1871
          SMMD
          Smart Medicine
          John Wiley and Sons Inc. (Hoboken )
          2751-1863
          2751-1871
          14 June 2023
          August 2023
          : 2
          : 3 ( doiID: 10.1002/smmd.v2.3 )
          : e20230016
          Affiliations
          [ 1 ] Department of Gastrointestinal Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang China
          [ 2 ] Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health) Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang China
          [ 3 ] Zhongshan‐Xuhui Hospital and the Shanghai Key Laboratory of Medical Epigenetics, the International Co‐laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology) Institutes of Biomedical Sciences Fudan University Shanghai China
          Author notes
          [*] [* ] Correspondence

          Luoran Shang, Zhongshan‐Xuhui Hospital and the Shanghai Key Laboratory of Medical Epigenetics, the International Co‐laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

          Email: luoranshang@ 123456fudan.edu.cn

          Weijian Sun, Department of Gastrointestinal Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

          Email: fame198288@ 123456126.com

          Author information
          https://orcid.org/0000-0002-8910-568X
          https://orcid.org/0000-0003-1786-8634
          https://orcid.org/0000-0001-7458-9100
          Article
          SMMD73
          10.1002/SMMD.20230016
          11236066
          39188343
          f2c47cc8-1049-440c-baa6-e38b0786317e
          © 2023 The Authors. Smart Medicine published by Wiley‐VCH GmbH on behalf of Wenzhou Institute, University of Chinese Academy of Sciences.

          This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

          History
          : 13 April 2023
          : 08 May 2023
          Page count
          Figures: 7, Tables: 0, Pages: 10, Words: 4986
          Categories
          Research Article
          Research Articles
          Custom metadata
          2.0
          August 2023
          Converter:WILEY_ML3GV2_TO_JATSPMC version:6.4.5 mode:remove_FC converted:05.07.2024

          gas therapy,microcarriers,microfluidic electrospray,multimodal tumor therapy,nitric oxide

          Comments

          Comment on this article

          scite_
          6
          0
          1
          0
          Smart Citations
          6
          0
          1
          0
          Citing PublicationsSupportingMentioningContrasting
          View Citations

          See how this article has been cited at scite.ai

          scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

          Similar content437