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      Inhibitory effect of Aucubin isolated from Eucommia ulmoides against UVB-induced matrix metalloproteinase-1 production in human skin fibroblasts.

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          Abstract

          Of 30 herbal plants tested, the methanol extracts of Eucommia ulmoides (52%), Evodia officinalis (45%), and Pleuropterus multiflorus (41%) each showed a potent inhibitory effect on the matrix metalloproteinase-1 (MMP-1) production in ultraviolet B (UVB)-irradiated human fibroblasts. Aucubin was isolated as the MMP-1 inhibitor from E. ulmoides, and significantly suppressed the production of MMP-1 by nearly 57% compared to the control. It also reduced MMP-1 mRNA expression. These results suggest that aucubin is a photoprotective phytochemical, and could be used as a potential agent in preventing photoaging.

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          Author and article information

          Journal
          Biosci Biotechnol Biochem
          Bioscience, biotechnology, and biochemistry
          Japan Society for Bioscience, Biotechnology, and Agrochemistry
          0916-8451
          0916-8451
          Nov 2005
          : 69
          : 11
          Affiliations
          [1 ] Department of Food Technology, Graduate School of Life Sciences and Biotechnology, Korea University, Seoul, Korea.
          Article
          JST.JSTAGE/bbb/69.2227
          10.1271/bbb.69.2227
          16306708
          ee30d2fa-07ef-4c5f-ba87-818b7d40d7dd
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