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      Induced production of a new polyketide in Penicillium sp. HS-11 by chemical epigenetic manipulation

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          Abstract

          <p class="first" id="d17898442e142">Chemical investigation into the culture broth of the plant endophyte Penicillium sp. HS-11 in the modified Martin's medium supplemented with subemylanilide hydroxamic acid (SAHA), a well-known histone deacetylase (HDACs) inhibitor, led to the isolation and identification of two induced products 4-epipenicillone B (1) and (R)-(+)-chrysogine (2). 4-epipenicillone B (1) was obtained as a new compound whose structure was elucidated by comprehensive spectroscopic methods including 1 D/2D NMR, HRESMS, and quantum chemistry calculations including DFT GIAO 13C NMR and ECD calculation. Acquisition of 4-epipenicillone B (1) enriched the chemical diversities of fungal natural products possessing a tricyclo [5.3.1.03,8] undecane skeleton. The cytotoxic activity of 1 was also evaluated. </p>

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          Author and article information

          Journal
          Natural Product Research
          Natural Product Research
          Informa UK Limited
          1478-6419
          1478-6427
          January 03 2020
          : 1-6
          Affiliations
          [1 ] College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China;
          [2 ] Department of Quality Management, Hangzhou Zhongmeihuadong China Pharmaceutical Co., Ltd, Hangzhou, P. R. China;
          [3 ] Xinjiang Laboratory of Special Environmental Microbiology, Institute of Microbiology, Xinjiang Academy of Agricultural Sciences, Urumqi, Xinjiang, P. R. China
          Article
          10.1080/14786419.2019.1709190
          31899961
          e3c135b6-193e-450b-996d-123d9001c26b
          © 2020
          History

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