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      Escin avoids hemorrhagic transformation in ischemic stroke by protecting BBB through the AMPK/Cav-1/MMP-9 pathway.

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          Abstract

          Hemorrhagic transformation (HT) seriously affects the clinical application of recombinant tissue plasminogen activator (rt-PA). The main strategy for combating HT is to keep the blood-brain barrier (BBB) stable. Escin is the active ingredient of Aesculus hippocastanum and a natural mixture of triterpene saponins, and may play a part in mitigation of HT.

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          Author and article information

          Journal
          Phytomedicine
          Phytomedicine : international journal of phytotherapy and phytopharmacology
          Elsevier BV
          1618-095X
          0944-7113
          Nov 2023
          : 120
          Affiliations
          [1 ] School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Qingquan Road 30, Yantai, Shandong 264005, PR China.
          [2 ] School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Qingquan Road 30, Yantai, Shandong 264005, PR China. Electronic address: wangyunjie@ytu.edu.cn.
          Article
          S0944-7113(23)00431-2
          10.1016/j.phymed.2023.155071
          37716034
          d8e39d80-58bd-492e-ae82-f52e7c922f6a
          History

          Hemorrhagic transformation,AMPK,Ischemic stroke,Cav-1,Escin
          Hemorrhagic transformation, AMPK, Ischemic stroke, Cav-1, Escin

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