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      Gender Differences in Patient‐Reported Outcomes Among Adults With Atherosclerotic Cardiovascular Disease

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          Abstract

          Background

          Atherosclerotic cardiovascular disease ( ASCVD) accounts for approximately one third of deaths in women. Although there is an established relationship between positive patient experiences, health‐related quality of life, and improved health outcomes, little is known about gender differences in patient‐reported outcomes among ASCVD patients. We therefore compared gender differences in patient‐centered outcomes among individuals with ASCVD.

          Methods and Results

          Data from the 2006 to 2015 Medical Expenditure Panel Survey, a nationally representative US sample, were used for this study. Adults ≥18 years with a diagnosis of ASCVD, ascertained by International Classification of Diseases, Ninth Revision ( ICD‐9) codes and/or self‐reported data, were included. Linear and logistic regression were used to compare self‐reported patient experience, perception of health, and health‐related quality of life by gender. Models adjusted for demographics, socioeconomic status, and comorbidities. There were 21 353 participants included, with >10 000 (47%‐weighted) of the participants being women, representing ≈11 million female adults with ASCVD nationwide. Compared with men, women with ASCVD were more likely to experience poor patient–provider communication (odds ratio 1.25 [95% confidence interval 1.11–1.41]), lower healthcare satisfaction (1.12 [1.02–1.24]), poor perception of health status (1.15 [1.04–1.28]), and lower health‐related quality of life scores. Women with ASCVD also had lower use of aspirin and statins, and greater odds of ≥2 Emergency Department visits/y.

          Conclusions

          Women with ASCVD were more likely to report poorer patient experience, lower health‐related quality of life, and poorer perception of their health when compared with men. These findings have important public health implications and require more research towards understanding the gender‐specific differences in healthcare quality, delivery, and ultimately health outcomes among individuals with ASCVD.

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          Most cited references48

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          Comparison of Hospital Mortality and Readmission Rates for Medicare Patients Treated by Male vs Female Physicians.

          Studies have found differences in practice patterns between male and female physicians, with female physicians more likely to adhere to clinical guidelines and evidence-based practice. However, whether patient outcomes differ between male and female physicians is largely unknown.
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            The role of pain and function in determining patient satisfaction after total knee replacement. Data from the National Joint Registry for England and Wales.

            A postal questionnaire was sent to 10,000 patients more than one year after their total knee replacement (TKR). They were assessed using the Oxford knee score and were asked whether they were satisfied, unsure or unsatisfied with their TKR. The response rate was 87.4% (8231 of 9417 eligible questionnaires) and a total of 81.8% (6625 of 8095) of patients were satisfied. Multivariable regression modelling showed that patients with higher scores relating to the pain and function elements of the Oxford knee score had a lower level of satisfaction (p < 0.001), and that ongoing pain was a stronger predictor of this. Female gender and a primary diagnosis of osteoarthritis were found to be predictors of lower levels of patient satisfaction. Differences in the rate of satisfaction were also observed in relation to age, the American Society of Anesthesiologists grade and the type of prosthesis. This study has provided data on the Oxford knee score and the expected levels of satisfaction at one year after TKR. The results should act as a benchmark of practice in the United Kingdom and provide a baseline for peer comparison between institutions.
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              Insights from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part II: gender differences in presentation, diagnosis, and outcome with regard to gender-based pathophysiology of atherosclerosis and macrovascular and microvascular coronary disease.

              Coronary heart disease is the leading cause of death and disability in the U.S., but recent advances have not led to declines in case fatality rates for women. The current review highlights gender-specific issues in ischemic heart disease (IHD) presentation, evaluation, and outcomes with a special focus on the results derived from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. In the second part of this review, we will assess new evidence on gender-based differences in vascular wall or metabolic alterations, atherosclerotic plaque deposition, and functional expression on worsening outcomes of women. Additionally, innovative cardiovascular imaging techniques will be discussed. Finally, we identify critical areas of further inquiry needed to advance this new gender-specific IHD understanding into improved outcomes for women.
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                Author and article information

                Contributors
                edonnell@jhmi.edu
                Journal
                J Am Heart Assoc
                J Am Heart Assoc
                10.1002/(ISSN)2047-9980
                JAH3
                ahaoa
                Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
                John Wiley and Sons Inc. (Hoboken )
                2047-9980
                10 December 2018
                18 December 2018
                : 7
                : 24 ( doiID: 10.1002/jah3.2018.7.issue-24 )
                : e010498
                Affiliations
                [ 1 ] Department of Internal Medicine East Carolina University Greenville NC
                [ 2 ] Center for Outcomes Research and Evaluation Yale New Haven Hospital New Haven CT
                [ 3 ] State House Annex Clinic Abuja Nigeria
                [ 4 ] Baptist Health South Florida Miami FL
                [ 5 ] Department of Medicine St. Luke's Hospital Chesterfield MO
                [ 6 ] Ciccarone Center for the Prevention of Cardiovascular Disease Johns Hopkins School of Medicine Baltimore MD
                [ 7 ] Department of Cardiology Lankenau Medical Center Wynnewood PA
                [ 8 ] West Virginia University Morgantown WV
                [ 9 ] Division of Cardiology University of Arizona College of Medicine Phoenix AZ
                [ 10 ] Division of Cardiology Yale School of Medicine New Haven CT
                [ 11 ] Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD
                Author notes
                [*] [* ] Correspondence to: Erin D. Michos, MD, MHS, Division of Cardiology, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins School of Medicine, Blalock 524‐B, 600 N. Wolfe St, Baltimore, MD. E‐mail: edonnell@ 123456jhmi.edu
                Article
                JAH33707
                10.1161/JAHA.118.010498
                6405598
                30561253
                d6f7a697-d2a5-4a1c-96d5-184d25777ac8
                © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                : 10 August 2018
                : 01 November 2018
                Page count
                Figures: 2, Tables: 4, Pages: 11, Words: 8217
                Funding
                Funded by: Blumenthal Scholars Fund for Preventive Cardiology Research
                Categories
                Original Research
                Original Research
                Health Services and Outcomes Research
                Custom metadata
                2.0
                jah33707
                18 December 2018
                Converter:WILEY_ML3GV2_TO_NLMPMC version:version=5.5.4 mode:remove_FC converted:18.12.2018

                Cardiovascular Medicine
                cardiovascular disease,health outcomes,health‐related quality of life,secondary prevention,women,quality and outcomes,health services

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