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      Continuous Glucose Monitor Interference With Commonly Prescribed Medications: A Pilot Study

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          Abstract

          Reliability of continuous glucose monitors (CGM) is a prerequisite for therapeutic dosing of insulin without the need for confirmatory blood glucose meter measurements. Interference of CGMs with commonly prescribed substances has not been extensively evaluated.

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          Glucose measurement: confounding issues in setting targets for inpatient management.

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            Effects of drugs on glucose measurements with handheld glucose meters and a portable glucose analyzer.

            Thirty drugs used primarily in critical care and hospital settings were tested in vitro to observe interference on glucose measurements with 6 hand-held glucose meters and a portable glucose analyzer. Paired differences of glucose measurements between drug-spiked samples and unspiked control samples were calculated to determine bias. A criterion of +/- 6 mg/dL was used as the cutoff for interference. Ascorbic acid interfered with the measurements on all glucose devices evaluated. Acetaminophen, dopamine, and mannitol interfered with glucose measurements on some devices. Dose-response relationships help assessment of drug interference in clinical use. High dosages of these drugs may be given to critically ill patients or self-administered by patients without medical supervision. Package inserts for the glucose devices may not provide adequate warning information. Hence, we recommend that clinicians choose glucose devices carefully and interpret results cautiously when glucose measurements are performed during or after drug interventions.
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              Direct Evidence of Acetaminophen Interference with Subcutaneous Glucose Sensing in Humans: A Pilot Study.

              Recent advances in accuracy and reliability of continuous glucose monitoring (CGM) devices have focused renewed interest on the use of such technology for therapeutic dosing of insulin without the need for independent confirmatory blood glucose meter measurements. An important issue that remains is the susceptibility of CGM devices to erroneous readings in the presence of common pharmacologic interferences. We report on a new method of assessing CGM sensor error to pharmacologic interferences using the example of oral administration of acetaminophen.
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                Author and article information

                Journal
                Journal of Diabetes Science and Technology
                J Diabetes Sci Technol
                SAGE Publications
                1932-2968
                1932-2968
                May 30 2016
                September 2017
                March 23 2017
                September 2017
                : 11
                : 5
                : 936-941
                Affiliations
                [1 ]Endocrine Research Unit, Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA
                [2 ]Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
                [3 ]Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
                [4 ]IDDM Consulting, Menlo Park, CA, USA
                [5 ]Department of Health Sciences Research, Mayo College, Rochester, MN, USA
                Article
                10.1177/1932296817697329
                5950984
                28332406
                ca2f04a6-d303-4b9c-9e4d-6b11a0d25122
                © 2017

                http://journals.sagepub.com/page/policies/text-and-data-mining-license

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