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      First Cytogenetic Profile of Omani Patients with de novo Myelodysplastic Syndromes : Comparison with data from Asia, Africa, Europe and North and South America

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          Abstract

          Clonal cytogenetic abnormalities have been reported among 30–80% of patients with myelodysplastic syndromes (MDS); however, 20–70% of patients with MDS show a normal karyotype that may nevertheless harbour a cryptic genetic alteration. Earlier reports have suggested that the distribution of specific chromosomal aberrations varies among Western and Asian countries, with geographical and ethnic differences in the frequency of specific chromosomal aberrations. This article compared the cytogenetic data of 36 adult Omani patients with MDS to previously reported data from other populations. Differences were noted between the percentages of clonal aberrations and the median age of Omani subjects at presentation in comparison to individuals of different ethnicities and from various geographical locations. To the best of the authors’ knowledge, this is the first report to describe the cytogenetic data of patients with MDS from Oman.

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          Author and article information

          Journal
          Sultan Qaboos Univ Med J
          Sultan Qaboos Univ Med J
          Sultan Qaboos University Medical Journal
          Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences
          2075-051X
          2075-0528
          August 2017
          10 October 2017
          : 17
          : 3
          : e286-e292
          Affiliations
          [1 ]Departments of Genetics, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman
          [2 ]Department of Malignancy Cytogenetics & Molecular Pathology, Hammersmith Hospital, Imperial College Healthcare National Health Service Trust, London, UK
          [3 ]Departments of Genetics Haematology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman
          [4 ]Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman
          Author notes
          [* ]Corresponding Author e-mail: uday.achandira@ 123456gmail.com
          Article
          PMC5642357 PMC5642357 5642357 squmj1708-e286-292
          10.18295/squmj.2017.17.03.005
          5642357
          29062550
          c3c9e741-eea2-4390-9929-412e3953880f
          © Copyright 2017, Sultan Qaboos University Medical Journal, All Rights Reserved
          History
          : 06 October 2016
          : 01 December 2016
          : 04 January 2017
          : 14 March 2017
          : 17 December 2016
          : 25 February 2016
          : 19 March 2017
          : 06 April 2017
          Categories
          Special Contribution

          Cytogenetic Abnormalities,Chromosomal Aberrations,Myelodysplastic Syndromes,Population Heterogeneity,Ethnic Groups,Oman

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