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Secondary use of electronic health records (EHRs) promises to advance clinical research and better inform clinical decision making. Challenges in summarizing and representing patient data prevent widespread practice of predictive modeling using EHRs. Here we present a novel unsupervised deep feature learning method to derive a general-purpose patient representation from EHR data that facilitates clinical predictive modeling. In particular, a three-layer stack of denoising autoencoders was used to capture hierarchical regularities and dependencies in the aggregated EHRs of about 700,000 patients from the Mount Sinai data warehouse. The result is a representation we name “deep patient”. We evaluated this representation as broadly predictive of health states by assessing the probability of patients to develop various diseases. We performed evaluation using 76,214 test patients comprising 78 diseases from diverse clinical domains and temporal windows. Our results significantly outperformed those achieved using representations based on raw EHR data and alternative feature learning strategies. Prediction performance for severe diabetes, schizophrenia, and various cancers were among the top performing. These findings indicate that deep learning applied to EHRs can derive patient representations that offer improved clinical predictions, and could provide a machine learning framework for augmenting clinical decision systems.
Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes over 300 contributions to the field, most of which appeared in the last year. We survey the use of deep learning for image classification, object detection, segmentation, registration, and other tasks and provide concise overviews of studies per application area. Open challenges and directions for future research are discussed.
Technological evolution of mobile user equipments (UEs), such as smartphones, laptops, etc., goes hand-in-hand with evolution of new mobile applications. However, running computationally demanding applications at the UEs is constrained by limited battery capacity and quite significant energy consumption of the UEs. Suitable solution extending the battery life-time of the UEs is to offload applications demanding huge processing to a conventional centralized cloud (CC). Nevertheless, this option introduces significant execution delay consisting in delivery of the offloaded applications to the cloud and back plus time of the computation at the cloud. Such delays are inconvenient and make the offloading unsuitable for real-time applications. To cope with the delay problem, a new emerging concept, known as mobile edge computing (MEC), has been introduced. The MEC brings computation and storage resources to the edge of mobile networks enabling to run highly demanding applications at the UE while meeting strict delay requirements. The MEC computing resources can be exploited also by operators and third parties for specific purposes. In this paper, we first describe major use cases and reference scenarios where the MEC is applicable. After that we survey existing concepts integrating MEC functionalities to the mobile networks and discuss current advancement in standardization of the MEC. The core of this survey is, then, focused on user-related research in the MEC, i.e., computation offloading. In this regard, we divide the research on computation offloading to three key areas: i) decision on computation offloading, ii) allocation of computing resource within the MEC, and iii) mobility management. Finally, we highlight lessons learned in area of the computation offloading and we discuss several open research challenges yet to be addressed in order to fully enjoy potentials offered by the MEC.
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