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      Pemphigus vegetans misdiagnosed as condylomata acuminata: A case report

      case-report

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          Abstract

          Pemphigus vegetans is a rare variant of pemphigus vulgaris, characterized by vegetating lesions primarily in the flexures. A 41‐year‐old male patient presented with pemphigus vegetans highly mimicking condylomata acuminata, which led to mistreatment. Careful analysis of clinical and laboratory findings enabled us to reach a correct diagnosis and successful treatment.

          Abstract

          Complete skin and mucosal examination should be performed on any patient complaining of suspicious warty lesions in the flexural area, and proper diagnostic methods are used for doubtful cases before performing any therapeutic intervention.

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          Most cited references12

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          Pemphigus vegetans: a clinical, histological, immunopathological and prognostic study.

          Pemphigus vegetans (P Veg) is a rare clinical form of pemphigus. Studies on P Veg are rare in the literature and none has so far evaluated the prognostic parameters.
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            Pemphigus vegetans. Neumann type and Hallopeau type.

            Two cases of pemphigus vegetans are presented, one of the Neumann type and one of the Hallopeau type. The differences between the two subsets are clinical presentation and course. Patients with the Hallopeau type often have a relatively benign disease, require lower doses of systemic corticosteroids, and usually have a prolonged remission. Patients with the Neumann type have a course similar to pemphigus vulgaris, need higher doses of systemic corticosteroids, and have relapses and remissions. The histologic findings in the vegetating lesions are similar in both types. The immunopathologic features of both types are indistinguishable and similar to pemphigus vulgaris. IgM staining of eosinophilic microabscesses was observed in one case.
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              Diagnosis and treatment of pemphigus.

              Pemphigus is an autoimmune bullous disease, in which autoantibodies react with the cell-cell adhesion structures, desmosomes, causing blisters and erosions on the oral mucosa and skin. Pemphigus is divided into two major subtypes: pemphigus vulgaris and pemphigus foliaceus. Oral corticosteroids are the primary treatment modality for pemphigus, while other therapeutic options, such as steroid pulse therapy, immunosuppressants, intravenous immunoglobulins, plasmapheresis and anti-CD20 monoclonal antibody therapy, are occasionally employed. Immunosuppressants used to treat pemphigus include azathioprine, cyclophosphamide, cyclosporine, mycophenolate mofetil and mizoribine. In this review, we summarize the current concepts of immunotherapy for the treatment of pemphigus in the Japanese population.
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                Author and article information

                Contributors
                reza_moeine_1987@yahoo.com
                Journal
                Clin Case Rep
                Clin Case Rep
                10.1002/(ISSN)2050-0904
                CCR3
                Clinical Case Reports
                John Wiley and Sons Inc. (Hoboken )
                2050-0904
                17 October 2022
                October 2022
                : 10
                : 10 ( doiID: 10.1002/ccr3.v10.10 )
                : e6393
                Affiliations
                [ 1 ] Department of Dermatology, Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences Isfahan Iran
                [ 2 ] Department of Dermatology Isfahan University of Medical Sciences Isfahan Iran
                [ 3 ] Thoracic and Vascular Surgery Research Center Shiraz University of Medical Sciences Shiraz Iran
                Author notes
                [*] [* ] Correspondence

                Reza Moeine; Resident of Dermatology, Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

                Email: reza_moeine_1987@ 123456yahoo.com

                Author information
                https://orcid.org/0000-0001-6829-8550
                https://orcid.org/0000-0001-5454-495X
                Article
                CCR36393 CCR3-2022-04-0981.R1
                10.1002/ccr3.6393
                9575105
                36258762
                b798ef1b-edbc-44c1-9973-c739df69f76f
                © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 09 September 2022
                : 30 April 2022
                : 21 September 2022
                Page count
                Figures: 4, Tables: 0, Pages: 4, Words: 1449
                Categories
                Case Report
                Case Report
                Custom metadata
                2.0
                October 2022
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.2.0 mode:remove_FC converted:17.10.2022

                condylomata acuminata,diagnosis,pemphigus vegetans
                condylomata acuminata, diagnosis, pemphigus vegetans

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