14
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Estimation of an Exposure Threshold Value for Compensation of Silica-Induced COPD Based on Longitudinal Changes in Pulmonary Function

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          (1) Background: To estimate the cumulative exposure to respirable crystalline silica (RCS) that reduces lung function to an extent corresponding with airway obstruction equivalent to chronic obstructive pulmonary disease (COPD). (2) Methods: The study is based on a miners’ cohort with longitudinal data on lung function and RCS exposure. Random-effects linear regression models, allowing for a possible threshold concerning the exposure concentration were used to analyze the impact of RCS on the ratio of forced expiratory volume in 1 s and forced vital capacity (FEV 1/FVC). The proposed threshold is the amount of RCS resulting in a decrease in FEV 1/FVC from the expected value to the lower limit of normal. (3) Results: The analysis shows that a threshold model fits the data significantly better than the usual linear model. The estimated threshold value for the exposure concentration is 0.089 mg/m 3. Using this threshold, the estimate for the corresponding reference dose for RCS is 2.33 mg/m 3·y. (4) Conclusions: The analysis confirmed that RCS has a negative impact on lung function. The effect is primarily due to exposure above a concentration threshold of 0.1 mg/m 3. It is recommended that COPD should be compensated as an occupational disease if cumulative exposure was at least 2 mg/m 3·y above this threshold.

          Related collections

          Most cited references30

          • Record: found
          • Abstract: found
          • Article: not found

          A new look at the statistical model identification

          IEEE Transactions on Automatic Control, 19(6), 716-723
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Estimating the Dimension of a Model

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations.

              The aim of the Task Force was to derive continuous prediction equations and their lower limits of normal for spirometric indices, which are applicable globally. Over 160,000 data points from 72 centres in 33 countries were shared with the European Respiratory Society Global Lung Function Initiative. Eliminating data that could not be used (mostly missing ethnic group, some outliers) left 97,759 records of healthy nonsmokers (55.3% females) aged 2.5-95 yrs. Lung function data were collated and prediction equations derived using the LMS method, which allows simultaneous modelling of the mean (mu), the coefficient of variation (sigma) and skewness (lambda) of a distribution family. After discarding 23,572 records, mostly because they could not be combined with other ethnic or geographic groups, reference equations were derived for healthy individuals aged 3-95 yrs for Caucasians (n=57,395), African-Americans (n=3,545), and North (n=4,992) and South East Asians (n=8,255). Forced expiratory value in 1 s (FEV(1)) and forced vital capacity (FVC) between ethnic groups differed proportionally from that in Caucasians, such that FEV(1)/FVC remained virtually independent of ethnic group. For individuals not represented by these four groups, or of mixed ethnic origins, a composite equation taken as the average of the above equations is provided to facilitate interpretation until a more appropriate solution is developed. Spirometric prediction equations for the 3-95-age range are now available that include appropriate age-dependent lower limits of normal. They can be applied globally to different ethnic groups. Additional data from the Indian subcontinent and Arabic, Polynesian and Latin American countries, as well as Africa will further improve these equations in the future.
                Bookmark

                Author and article information

                Journal
                Int J Environ Res Public Health
                Int J Environ Res Public Health
                ijerph
                International Journal of Environmental Research and Public Health
                MDPI
                1661-7827
                1660-4601
                04 December 2020
                December 2020
                : 17
                : 23
                : 9040
                Affiliations
                [1 ]Division Work and Health, Federal Institute for Occupational Safety and Health, D-10317 Berlin, Germany
                [2 ]Institute and Clinic for Occupational, Social and Environmental Medicine, Clinical Centre of the Ludwig Maximilian University Munich, D-80539 Munich, Germany; Dennis.Nowak@ 123456med-uni-muenchen.de
                [3 ]Comprehensive Pneumology Center (CPC) Munich, German Center for Lung Research (DZL), D-81377 Munich, Germany
                Author notes
                [* ]Correspondence: Moehner.Matthias@ 123456baua.bund.de ; Tel.: +49-30-515484161
                Author information
                https://orcid.org/0000-0003-3225-5879
                Article
                ijerph-17-09040
                10.3390/ijerph17239040
                7729997
                33291582
                aea3ce8b-2c43-4b00-8d2a-858b9715096a
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 14 October 2020
                : 02 December 2020
                Categories
                Article

                Public health
                chronic obstructive pulmonary disease,respirable crystalline silica,threshold models,epidemiology,compensation

                Comments

                Comment on this article