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      Introducing the tablet-based Oxford Cognitive Screen-Plus (OCS-Plus) as an assessment tool for subtle cognitive impairments

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          Abstract

          Here, we present the Oxford Cognitive Screen-Plus, a computerised tablet-based screen designed to briefly assess domain-general cognition and provide more fine-grained measures of memory and executive function. The OCS-Plus was designed to sensitively screen for cognitive impairments and provide a differentiation between memory and executive deficits. The OCS-Plus contains 10 subtasks and requires on average 24 min to complete. In this study, 320 neurologically healthy ageing participants (age M = 62.66 , SD = 13.75) from three sites completed the OCS-Plus. The convergent validity of this assessment was established in comparison to the ACE-R, CERAD and Rey–Osterrieth. Divergent validity was established through comparison with the BDI and tests measuring divergent cognitive domains. Internal consistency of each subtask was evaluated, and test–retest reliability was determined. We established the normative impairment cut-offs for each of the subtasks. Predicted convergent and divergent validity was found, high internal consistency for most measures was also found with the exception of restricted range tasks, as well as strong test–retest reliability, which provided evidence of test stability. Further research demonstrating the use and validity of the OCS-Plus in various clinical populations is required. The OCS-Plus is presented as a standardised cognitive assessment tool, normed and validated in a sample of neurologically healthy participants. The OCS-Plus will be available as an Android App and provides an automated report of domain-general cognitive impairments in executive attention and memory.

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          Most cited references41

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          The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.

          To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia. Validation study. A community clinic and an academic center. Ninety-four patients meeting MCI clinical criteria supported by psychometric measures, 93 patients with mild Alzheimer's disease (AD) (Mini-Mental State Examination (MMSE) score > or =17), and 90 healthy elderly controls (NC). The MoCA and MMSE were administered to all participants, and sensitivity and specificity of both measures were assessed for detection of MCI and mild AD. Using a cutoff score 26, the MMSE had a sensitivity of 18% to detect MCI, whereas the MoCA detected 90% of MCI subjects. In the mild AD group, the MMSE had a sensitivity of 78%, whereas the MoCA detected 100%. Specificity was excellent for both MMSE and MoCA (100% and 87%, respectively). MCI as an entity is evolving and somewhat controversial. The MoCA is a brief cognitive screening tool with high sensitivity and specificity for detecting MCI as currently conceptualized in patients performing in the normal range on the MMSE.
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            "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.

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              An inventory for measuring depression.

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                Author and article information

                Contributors
                nele.demeyere@psy.ox.ac.uk
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                12 April 2021
                12 April 2021
                2021
                : 11
                : 8000
                Affiliations
                [1 ]GRID grid.4991.5, ISNI 0000 0004 1936 8948, Department of Experimental Psychology, , University of Oxford, ; New Radcliffe House, Radcliffe Observatory Quarter, Oxford, OX2 6AE UK
                [2 ]GRID grid.5252.0, ISNI 0000 0004 1936 973X, Department of General and Experimental Psychology, , Ludwig-Maximilians-Universität München, ; Munich, Germany
                [3 ]GRID grid.8096.7, ISNI 0000000106754565, Coventry University, ; Coventry, UK
                [4 ]GRID grid.275559.9, ISNI 0000 0000 8517 6224, Hans-Berger Department of Neurology, , Jena University Hospital, ; Jena, Germany
                [5 ]GRID grid.4991.5, ISNI 0000 0004 1936 8948, Department of Computer Science, University of Oxford, , Wolfson Building, ; Parks Road, Oxford, OX1 3QD UK
                Article
                87287
                10.1038/s41598-021-87287-8
                8041764
                33414495
                ae13eb8c-5b74-413d-8309-7e854b66312f
                © The Author(s) 2021

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 16 November 2020
                : 24 March 2021
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100000364, Stroke Association;
                Award ID: TSA2015_LECT02; SA PPA 18\100032
                Award Recipient :
                Categories
                Article
                Custom metadata
                © The Author(s) 2021

                Uncategorized
                cognitive ageing,diagnosis
                Uncategorized
                cognitive ageing, diagnosis

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