6
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Paraventricular and Supraoptic Nuclei of the Hypothalamus Are Not Equally Important for Oxytocin Release during Stress

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The relative importance of the paraventricular (PVN) and the supraoptic nuclei (SON) for the secretion of oxytocin was evaluated by comparison of stress-induced oxytocin release under normal conditions, in the absence of vasopressin and/or corticoliberin (CRF). We introduced an incomplete anterolateral cut (iALC) around the mediobasal hypothalamus designed to leave intact the SON-neurohypophysial connections but to inflict damage to the nerve fibers from the PVN. The studies were performed in conscious cannulated rats using immobilization as the stress stimulus. Stress-induced oxytocin release was found in heterozygous Brattleboro rats as well as in homozygous animals lacking vasopressin, yet in the latter it was less pronounced and in both cases it was prevented by iALC. In Wistar rats, stress-induced oxytocin release was markedly reduced after iALC and absent after PVN lesion. Both hypothalamic interventions failed to influence basal oxytocin levels and resulted in a similar reduction of ACTH release. It is concluded that a functional diversity exists between the hypothalamic magnocellular nuclei. At least in relation to immobilization stress, the PVN is essential for stress-induced oxytocin release and it is evident that the SON without the PVN cannot preserve oxytocin secretion during stress.

          Related collections

          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1993
          1993
          08 April 2008
          : 57
          : 5
          : 776-781
          Affiliations
          aInstitute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia; bInstitute of Experimental Medicine, Budapest, Hungary
          Article
          126436 Neuroendocrinology 1993;57:776–781
          10.1159/000126436
          8413814
          a583cbe7-862c-48dd-a9fc-98dcde72ed38
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 21 April 1992
          : 20 November 1992
          Page count
          Pages: 6
          Categories
          Original Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Vasopressin,Stress,Brattleboro rats,Oxytocin ACTH,Paraventricular nucleus,Corticoliberin,Supraoptic nucleus

          Comments

          Comment on this article