11
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study

      research-article
      1 , 2 , 3 , , 4 , 5 , 6 , 1 , 2 , 1 , 1 , 5 , 5 , 7 , 8 , 8 , 5 , 5 , 5 , 9 , 10 , 7 , 8 , 11 , 12 , 13 , 9 , 14 , 15 , 16 , 17 , 18 , 1 , 1 , 19 , 20 , 1 , 3 , 21 , the PRONIA Consortium
      European Archives of Psychiatry and Clinical Neuroscience
      Springer Berlin Heidelberg
      Formal thought disorder, Early psychosis, Clustering, Functioning, Neurocognition

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Formal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition.

          Methods

          279 patients with ROP were recruited as part of the multi-site European PRONIA study (Personalised Prognostic Tools for Early Psychosis Management; www.pronia.eu). Five FTD-related symptoms (conceptual disorganization, poverty of content of speech, difficulty in abstract thinking, increased latency of response and poverty of speech) were assessed with Positive and Negative Symptom Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS).

          Results

          The results with two patient subgroups showing different levels of FTD were the most stable and generalizable clustering solution (predicted clustering strength value = 0.86). FTD-High subgroup had lower scores in social ( p fdr < 0.001) and role ( p fdr < 0.001) functioning, as well as worse neurocognitive performance in semantic ( p fdr < 0.001) and phonological verbal fluency ( p fdr < 0.001), short-term verbal memory ( p fdr = 0.002) and abstract thinking ( p fdr = 0.010), in comparison to FTD-Low group.

          Conclusions

          Clustering techniques allowed us to identify patients with more pronounced FTD showing more severe deficits in functioning and neurocognition, thus suggesting that FTD may be a relevant marker of illness severity in the early psychosis pathway.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s00406-021-01327-y.

          Related collections

          Most cited references53

          • Record: found
          • Abstract: not found
          • Article: not found

          Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Silhouettes: A graphical aid to the interpretation and validation of cluster analysis

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other

                Bookmark

                Author and article information

                Contributors
                oemer.oeztuerk@med.uni-muenchen.de
                Journal
                Eur Arch Psychiatry Clin Neurosci
                Eur Arch Psychiatry Clin Neurosci
                European Archives of Psychiatry and Clinical Neuroscience
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                0940-1334
                1433-8491
                17 September 2021
                17 September 2021
                2022
                : 272
                : 3
                : 403-413
                Affiliations
                [1 ]GRID grid.5252.0, ISNI 0000 0004 1936 973X, Department of Psychiatry and Psychotherapy, , Ludwig-Maximilian-University Munich, ; Nussbaumstr. 7, 80336 Munich, Germany
                [2 ]GRID grid.4372.2, ISNI 0000 0001 2105 1091, International Max Planck Research School for Translational Psychiatry, ; Munich, Germany
                [3 ]GRID grid.419548.5, ISNI 0000 0000 9497 5095, Max Planck Institute for Psychiatry, ; Munich, Germany
                [4 ]GRID grid.462365.0, ISNI 0000 0004 1790 9464, MoMiLab Research Unit, , IMT School for Advanced Studies Lucca, ; Lucca, Italy
                [5 ]GRID grid.6190.e, ISNI 0000 0000 8580 3777, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital of Cologne, , University of Cologne, ; Cologne, Germany
                [6 ]GRID grid.59734.3c, ISNI 0000 0001 0670 2351, Department of Psychiatry, , Icahn School of Medicine at Mount Sinai, ; New York, USA
                [7 ]GRID grid.7273.1, ISNI 0000 0004 0376 4727, School of Psychology, , Aston University, ; Birmingham, UK
                [8 ]GRID grid.6572.6, ISNI 0000 0004 1936 7486, Institute for Mental Health, , University of Birmingham, ; Birmingham, UK
                [9 ]GRID grid.411327.2, ISNI 0000 0001 2176 9917, Department of Psychiatry and Psychotherapy, Medical Faculty, , Heinrich-Heine University, ; Düsseldorf, Germany
                [10 ]GRID grid.4563.4, ISNI 0000 0004 1936 8868, Division of Psychiatry and Applied Psychology, Institute of Mental Health, , University of Nottingham, ; Nottingham, UK
                [11 ]GRID grid.1374.1, ISNI 0000 0001 2097 1371, Department of Psychiatry, , University of Turku, ; Turku, Finland
                [12 ]GRID grid.1008.9, ISNI 0000 0001 2179 088X, Melbourne Neuropsychiatry Centre, , University of Melbourne, ; Melbourne, Australia
                [13 ]GRID grid.429299.d, ISNI 0000 0004 0452 651X, Melbourne Health, ; Melbourne, Australia
                [14 ]GRID grid.6572.6, ISNI 0000 0004 1936 7486, School of Psychology, , University of Birmingham, ; Birmingham, UK
                [15 ]GRID grid.488501.0, ISNI 0000 0004 8032 6923, Orygen, , The National Centre of Excellence for Youth Mental Health, ; Melbourne, Australia
                [16 ]GRID grid.1008.9, ISNI 0000 0001 2179 088X, Centre for Youth Mental Health, , University of Melbourne, ; Melbourne, Australia
                [17 ]Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
                [18 ]GRID grid.412556.1, ISNI 0000 0004 0479 0775, Department of Psychiatry, , University Psychiatric Clinic, Psychiatric University Hospital, University of Basel, ; Basel, Switzerland
                [19 ]GRID grid.7644.1, ISNI 0000 0001 0120 3326, Department of Basic Medical Sciences, Neuroscience and Sense Organs, , University of Bari “Aldo Moro”, ; Bari, Italy
                [20 ]GRID grid.7644.1, ISNI 0000 0001 0120 3326, Department of Education, Psychology and Communication Science, , University of Bari “Aldo Moro”, ; Bari, Italy
                [21 ]GRID grid.13097.3c, ISNI 0000 0001 2322 6764, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, , King’s College London, ; London, UK
                Author information
                http://orcid.org/0000-0003-3665-0526
                Article
                1327
                10.1007/s00406-021-01327-y
                8938366
                34535813
                93c22bc8-25cd-4aad-b006-5e159fa543c7
                © The Author(s) 2021

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 1 May 2021
                : 27 August 2021
                Funding
                Funded by: the Structural European Funding of the Italian Minister of Education (Attraction and International Mobility – AIM - action
                Award ID: 1859959
                Award Recipient :
                Funded by: Clinician Scientist Program funded by the Else-Kröner-Fresenius-Stiftung
                Funded by: Ludwig-Maximilians-Universität München (1024)
                Categories
                Original Paper
                Custom metadata
                © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022

                Neurosciences
                formal thought disorder,early psychosis,clustering,functioning,neurocognition
                Neurosciences
                formal thought disorder, early psychosis, clustering, functioning, neurocognition

                Comments

                Comment on this article

                scite_
                0
                0
                0
                0
                Smart Citations
                0
                0
                0
                0
                Citing PublicationsSupportingMentioningContrasting
                View Citations

                See how this article has been cited at scite.ai

                scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

                Similar content185

                Cited by5

                Most referenced authors1,058