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      Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

      1 , , ,
      Immunology today
      Elsevier BV

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          Abstract

          Pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell-mediated immunity. Since TH1 cytokines compromise pregnancy and TH2 cytokines are produced at the maternal-fetal interface, we hypothesize that these TH2 cytokines inhibit TH1 responses, improving fetal survival but impairing responses against some pathogens.

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          Author and article information

          Journal
          Immunol Today
          Immunology today
          Elsevier BV
          0167-5699
          0167-5699
          Jul 1993
          : 14
          : 7
          Affiliations
          [1 ] Dept of Immunology, University of Alberta, Edmonton, Canada.
          Article
          0167-5699(93)90235-D
          10.1016/0167-5699(93)90235-D
          8363725
          87725700-4ce3-4bfc-b527-142d1d12334e
          History

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