This is the fourth paper of our new release of the BaSTI (a Bag of Stellar Tracks and Isochrones) stellar model and isochrone library. Following the updated solar-scaled, alpha-enhanced, and white dwarf model libraries, we present here alpha-depleted ([alpha/Fe] = -0.2) evolutionary tracks and isochrones, suitable to study the alpha-depleted stars discovered in Local Group dwarf galaxies and in the Milky Way. These calculations include all improvements and updates of the solar-scaled and alpha-enhanced models, and span a mass range between 0.1 and 15 Msun, 21 metallicities between [Fe/H] = -3.20 and +0.45 with a helium-to-metal enrichment ratio dY/dZ = 1.31, homogeneous with the solar-scaled and alpha-enhanced models. The isochrones -- available in several photometric filters -- cover an age range between 20 Myr and 14.5 Gyr, including the pre-main-sequence phase. We have compared our isochrones with independent calculations of alpha-depleted stellar models, available for the same alpha-element depletion adopted in present investigation. We have also discussed the effect of an alpha-depleted heavy element distribution on the bolometric corrections in different wavelength regimes. Our alpha-depleted evolutionary tracks and isochrones are publicly available at the BaSTI website.