Primary cytoreductive surgery and adjuvant hormonal monotherapy in women with advanced low-grade serous ovarian carcinoma: Reducing overtreatment without compromising survival?

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Women with advanced-stage, low-grade serous ovarian carcinoma (LGSC) have low chemotherapy response rates and poor overall survival. Most LGSC tumors overexpress hormone receptors, which represent a potential treatment target. Our study objective was to determine the outcomes of patients with advanced-stage LGSC treated with primary cytoreductive surgery (CRS) and hormone therapy (HT).

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Gynecol. Oncol.

Title: Gynecologic oncology

Publisher: Elsevier BV

ISSN (Electronic): 1095-6859

ISSN (Print): 0090-8258

Publication date (Electronic): October 2017

Volume: 147

Issue: 1

Affiliations

[1 ] Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: afader1@jhmi.edu.

[2 ] Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.

[3 ] Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH, USA.

[4 ] Department of Gynecologic Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

[5 ] Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

[6 ] Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.

[7 ] Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Article

Publisher Item ID: S0090-8258(17)31167-8

DOI: 10.1016/j.ygyno.2017.07.127

PubMed ID: 28768570

SO-VID: 706a28dd-96d6-4dfb-92e3-5642ab0af9bc

History

Keywords: Hormonal therapy,Cytoreductive surgery,Ovarian cancer,Low-grade serous carcinoma

Data availability:

Keywords: Hormonal therapy, Cytoreductive surgery, Ovarian cancer, Low-grade serous carcinoma

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Cited by 36

See all cited by