The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach.
Participants of the SPIN cohort provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological and neuropsychological evaluations, and undergo a structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video-polysomnogram, 18F-fluorodeoxyglucose PET, amyloid PET, Tau PET). Participants are followed annually for a minimum of 4 years, with repeated cerebrospinal fluid collection and imaging studies performed every other year, and brain donation is encouraged.
The SPIN cohort is a multimodal biomarker program for research in neurodegeneration.
We describe how research projects were unified under an umbrella biomarker program.
Integrating clinical and biological data allows discovery and validation of markers.
As a clinical group, we keep the SPIN cohort focused in patient-oriented research.
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