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      Atrophic dermatofibrosarcoma protuberans with the fusion gene COL1A1-PDGFB detected by RT-PCR using only a single primer pair.

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          Abstract

          Dermatofibrosarcoma protuberans (DFSPs) is an uncommon dermal tumor of intermediate to low-grade malignancy. A few patients have clinically persistent plaques that might be atrophic, and they are difficult to be diagnosed clinically. With the development of cytogenetic and molecular biology techniques, the detection of fusion transcripts of the collagen type 1a1 (COL1A1) and platelet-derived growth factor-BB (PDGFB) genes has been recognized as a reliable and valuable molecular tool for the diagnosis of DFSPs. We reported a 24-year-old woman who had a 2 years history of atrophic DFSPs, and detected the gene fusion between COL1A1 to PDGFB by one-step method of RT-PCR using only a single primer pair. The gene fusion detected by this rapid and efficient one-step method in our patient appears to be the first report of atrophic DFSPs, and we detected a novel COL1A1 breakpoint between exon 2 and exon 3.

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          Author and article information

          Journal
          Int J Clin Exp Pathol
          International journal of clinical and experimental pathology
          1936-2625
          1936-2625
          2015
          : 8
          : 6
          Affiliations
          [1 ] Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University Beijing 100010, China ; Department of Dermatology, Beijing Electric Power Hospital Beijing 100073, China.
          [2 ] Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University Beijing 100010, China.
          Article
          4525987
          26261653
          6e7e26de-225c-4374-958b-268561465c6a
          History

          RT-PCR,Dermatofibrosarcoma protuberans,COL1A1-PDGFB,CD34,atrophic

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