42
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Helicobacter pylori and gastric cancer: possible role of microRNAs in this intimate relationship.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Chronic infection by Helicobacter pylori is a major risk factor for gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. H. pylori possesses a set of virulence factors, including the CagA effector, which interferes with intracellular signalling pathways and mediates phenotypic alterations, strongly evoking neoplasic transformation. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression involved in development, cell proliferation and immune responses. miRNAs are frequently altered in cancers, revealing their functions as oncogenes or tumour suppressors. However, the role, if any, that miRNAs play in the host cell responses to H. pylori remains unknown. This review considers the possible involvement of some miRNAs, including miR-146, miR-155, miR-21, miR-27a, miR-106-93-25 and miR-221-222 clusters and the miR-200 family in H. pylori-induced infection and gastric cancers. Further exploration of miRNA-mediated gene silencing, taking into account the relationship between host targets and bacterial effectors, will most certainly bring new insights into the control of gene expression in human gastric cells chronically infected by H. pylori.

          Related collections

          Author and article information

          Journal
          Clin Microbiol Infect
          Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
          Wiley
          1469-0691
          1198-743X
          Sep 2009
          : 15
          : 9
          Affiliations
          [1 ] INSERM U869, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, Bordeaux, France.
          Article
          S1198-743X(14)60891-0
          10.1111/j.1469-0691.2009.02960.x
          19702585
          563da194-bba0-423d-b88c-8add80395f7c
          History

          Comments

          Comment on this article